Research projects
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At The Florey we research a broad range of topics. We aim to advance brain research on all frontiers – from fundamental research, to drug discovery and clinical work. Explore our scientists’ remarkable work over 200+ projects.
Research projects
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CaMKK2 control of neuronal function and complex behaviour in health and disease
This multidisciplinary project will identify the key role of the enzyme, CaMKK2, in the regulation of mouse brain function and behaviour, and provide novel insights into the cause and treatment of clinical psychiatric disorders.
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Can mice really play ipad games for milkshake rewards and how can this help us understand motivation in Autism Spectrum Disorder?
What underlies motivation impairments in a mouse model containing an ASD associated mutation?
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Can we achieve precise medication use in people living with Alzheimer’s disease?
Alzheimer’s disease (AD) is the most common form of dementia, affecting 1 in 9 people >65 years. AD is featured by progressive neuron loss in the brain and decline in cognitive function. However, recent evidence suggests that AD may also affect peripheral organs. In line with this, we have for the first time demonstrated that the expression and function of drug transporters and metabolising…
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Can we identify novel biomarkers for early detection of Alzheimer’s disease (AD) by targeting the brain-draining lymph nodes?
Alzheimer's disease (AD) affects >55 million people globally, placing a heavy socioeconomic burden on all countries. The majority of clinical trials for the treatment of AD have reported minimal benefits. One of the major reasons was that the recruited patients were at late disease stage with irreversible damage to the brain. They have also shown that better therapeutic outcomes can be achieved in…
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Cell therapy for brain repair focussing on Parkinson’s disease
Proof of principle for cell replacement therapy in the treatment of Parkinson’s disease was first demonstrated in the clinic using human fetal tissue in the 1980’s.
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