Research projects
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At The Florey we research a broad range of topics. We aim to advance brain research on all frontiers – from fundamental research, to drug discovery and clinical work. Explore our scientists’ remarkable work over 200+ projects.
Research projects
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Biomarker discovery for neurodegenerative disease
Alzheimer’s disease is a debilitating slow neurodegenerative disease that is the leading cause of dementia. This disease is characterized by a slow decline in cognitive function, with the greatest risk factor for the disease being age.
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Biophysics of leaky HCN ion channels
The hyperpolarisation-activated, cyclic nucleotide-gated (HCN) channel, opens and conducts positively charged ions when the transmembrane voltage is negative on the inside. Several variants in the HCN1 subtype channel have been reported in patients with severe epilepsy. Functional analyses of these variants revealed a converging functional impact of ‘leaky’ channels, which remain open and conduct ions at…
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Blood testing to predict and discriminate dementias
The aim of this project is to develop a blood test to enable earlier diagnosis of Alzheimer’s disease, improve clinical screening and drug development.
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CaMKK2 control of neuronal function and complex behaviour in health and disease
This multidisciplinary project will identify the key role of the enzyme, CaMKK2, in the regulation of mouse brain function and behaviour, and provide novel insights into the cause and treatment of clinical psychiatric disorders.
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Can mice really play ipad games for milkshake rewards and how can this help us understand motivation in autism spectrum disorder?
What underlies motivation impairments in a mouse model containing an ASD associated mutation?
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