Research projects
Page 4
At The Florey we research a broad range of topics. We aim to advance brain research on all frontiers – from fundamental research, to drug discovery and clinical work. Explore our scientists’ remarkable work over 200+ projects.
Research projects
-
Bioengineered scaffolds for brain repair
We are developing and testing various nanofibrous scaffolds and hydrogels to provide structural support for stem cells and differentiating neurons in the injured brain.
Learn moreAccepting students -
Biological inorganic chemistry of copper in the early ubiquitination pathways
The ubiquitination pathway is an essential post-translational modification (poly-ubiquitination) process for subsequent degradation of proteins by the proteasome.
Learn more -
Biomarker discovery for neurodegenerative disease
Alzheimer’s disease is a debilitating slow neurodegenerative disease that is the leading cause of dementia. This disease is characterized by a slow decline in cognitive function, with the greatest risk factor for the disease being age.
Learn more -
Biophysics of leaky HCN ion channels
The hyperpolarisation-activated, cyclic nucleotide-gated (HCN) channel, opens and conducts positively charged ions when the transmembrane voltage is negative on the inside. Several variants in the HCN1 subtype channel have been reported in patients with severe epilepsy. Functional analyses of these variants revealed a converging functional impact of ‘leaky’ channels, which remain open and conduct ions at…
Learn more -
Blood testing to predict and discriminate dementias
The aim of this project is to develop a blood test to enable earlier diagnosis of Alzheimer’s disease, improve clinical screening and drug development.
Learn more