Research projects
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At The Florey we research a broad range of topics. We aim to advance brain research on all frontiers – from fundamental research, to drug discovery and clinical work. Explore our scientists’ remarkable work over 200+ projects.
Research projects
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Development of antisense oligonucleotides as a potential treatment of Parkinson’s disease
In this project, we aim to design and synthesise a novel class of ASO based on peptide nucleic acid (PNA) to block alpha-synuclein mRNA and reduce the level of alpha-synuclein.
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Development of novel therapeutic antibodies targeting tau
This project aims to develop novel tau intrabodies and characterise their expression and functionality within neurons.
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Development of peptide-oligonucleotide conjugates to target poly (ADP-ribose) polymerase for new RNA-based amyotrophic lateral sclerosis therapy
The project aims to use oligonucleotide-based therapeutic approach to knock down the level of polymerase (PARP).
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Disorders of the stomach, gastroparesis and other challenges
This Florey project will use novel approaches to investigate the underlying pathophysiology of gastroparesis across the different gastroparesis subtypes.
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Does ApoE promote phagocytic degradation of amyloid-beta?
This study will investigate the development of a therapeutic strategy targeting Aβ phagocytic degradation with apoE for treating Alzheimer’s disease.
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