Investigating how neurons die in Alzheimer’s disease
Alzheimer’s disease stands out as a major disease without effective treatments. Understanding the biochemical mechanisms that lead to neurodegeneration may provide new opportunities for treatments.
We have recently found that the major genes involved in Alzheimer’s disease are involved in regulating the cell death pathway, ferroptosis. This project will use molecular and cell biology approaches to understand the molecular mechanisms underlying how these Alzheimer’s genes may impact ferroptotic neurodegeneration in Alzheimer’s disease, and seek to discover new therapeutic targets and treatments.
To investigate the role of the apolipoprotein E (APOE) gene and its receptors in ferroptotic cell death.
Take part in this project
Students who are applying to study at The Florey can register their interest in this project. Refer to our step-by-step guide to help you with your application.
Associate Professor Scott Ayton
Dr Abdel Ali Belaidi