Dr Abdel Ali Belaidi

Senior Research Fellow

Parkville Campus
30 Royal Parade
Parkville Victoria 3052

Abdel Ali Belaidi profile


Dr Abdel Ali Belaidi is a Senior Research Fellow at The Florey and his research interests focus around apolipoprotein E and apolipoprotein E receptors and their association with neurodegeneration with a special focus on Alzheimer’s disease.

Abdel completed a licentiate in Biology in Morocco, a diploma in Biology and a PhD in Biochemistry at the University of Cologne, Germany. During his PhD and postdoctoral research, Abdel investigated molybdenum and sulphur amino acid metabolism and associated neurodegenerative diseases. His research resulted in significant novel biochemical and clinical findings and has been translated to the development of the first successful therapy of human molybdenum cofactor deficiency type A, which was published in Lancet and recently approved by FDA.

Abdel moved from Germany to Australia and joined The Florey in 2014 after receiving an international Postdoctoral Fellowship from the German Research Foundation (DFG) for investigating the link between iron and neurodegenerative diseases and he received further international research funding from the Alzheimer’s Association to investigate apolipoprotein E and apolipoprotein E receptors link to Alzheimer’s disease. His achievements in this area included the identification of apolipoprotein E as a potent inhibitor of a cell death termed ferroptosis, which results from the iron-dependent oxidation of lipids in neurons.

Abdel has a strong interest in investigating cell metabolism and cell death mechanisms implicated in neurodegeneration with particular interest in understanding the cross talk between cysteine, lipid and iron metabolism in determining neuronal susceptibility to cell death.

Career highlights

Current roles

  • Senior Research Fellow, The Florey
  • Full member, Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART)
  • Full member, the International Society of Neurochemistry (ISN)
  • Associate editor,  Frontiers in Neuroscience, section Neurodegeneration

Other highlights

From basic research to FDA approval: Abdel’s research translated into the development of the first successful treatment of molybdenum cofactor deficiency type A, which has been published in Lancet in 2015 and has been approved as a treatment by FDA in 2021. His research identified also excitotoxicity as a mechanism of neurodegeneration molybdenum cofactor deficiency and introduced NMDA receptor antagonists as possible treatment, which has been published in journal of clinical investigation in 2017

Invited speaker: International Society of Neurochemistry and European Society of Neurochemistry, ISN-ESN 2023 in Porto, Portugal (2023); International Conference on Biological Inorganic Chemistry, ICBIC 2023, in Adelaide, Australia (2023); Australian Dementia Research Forum 2023, Gold coast, Australia (2023); ComBio2022 (Australian Society for Biochemistry and Molecular Biology), in Melbourne, Australia (2022); Neuroscience Seminar Series, The University of Melbourne, Melbourne, Australia (2019). Melbourne BioMetals Symposium, Melbourne, Australia (2016); International Conference on Molybdenum & Tungsten Enzymes, in Balatonfüred, Hungary (2015)

Awards and achievements

  • 2023 – International Emerging Group Leader Symposia award (EGLS) from the international Society of Neurochemistry (ISN) Travel award (Geneva, Switzerland)
  • 2021 – International Alzheimer’s Association Research Grant: 3 years (Chicago, United States)
  • 2021 – Alan Rembach Postdoctoral Travel Scholarship (Melbourne, Australia)
  • 2020 – Florey COVID-19 Rebound grants to support research costs (Melbourne, Australia)
  • 2016 – International Alzheimer’s Association Research Fellowship: 3 years (Chicago, United States)
  • 2014 – International Postdoctoral fellowship of the German Research Foundation: 2 years (Bonn, Germany)
  • 2012 – Travel Award from the Cologne Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases (Cologne, Germany)
  • 2011 – outstanding academic qualification “Suma cum Laude” for PhD in Biochemistry, Faculty of Mathematics and Natural Sciences, University of Cologne (Cologne, Germany)
  • 2008 –”Chemicus award” of the University of Cologne for best graduate student work and presentation (Cologne, Germany)

Research publications


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