Florey scientists have uncovered elevated intracranial pressure as a previously unrecognised cause of brain dysfunction in sepsis. The researchers used a Florey-patented drug to rapidly restore brain pressure in preclinical sepsis. The promising treatment - already being tested in an Australia-wide sepsis clinical trial - could also help patients with traumatic brain…
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Stem cell therapy is an innovative approach that uses healthy cells to replace those lost due to disease. Rejection from the body's immune system, however, presents a major challenge. Florey researchers are working on therapies which involve the transplantation of dopamine-releasing neurons with the potential to repair brain damage caused by Parkinson's disease. The transplanted cells are…
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A new five-year $4.6 million research program, supported by the Australian Government's Medical Research Future Fund, will test whether an innovative stem cell therapy can reverse the devastating effects of Parkinson’s disease. Developed by iCamuno Biotherapeutics, the therapy will be evaluated in preclinical studies with partners at Monash University, The Florey, the University…
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Professor Anthony Hannan heads The Florey’s Epigenetics and Neural Plasticity Group and is a leading researcher in a field of study known as paternal immune activation (PIA). His team has used mouse models to show genes and life experiences, including exposure to infections such as COVID‑19, can alter sperm epigenetics and affect offspring brain development and behaviour.…
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The Australian Commission on Safety and Quality in Health Care has released updated national clinical care guidelines to support people recovering from stroke. Experts from the Australian Stroke Clinical Registry (AuSCR), a collaborative partnership led by The Florey, have helped strengthen the Stroke Clinical Care Standard using national data collected from hospitals and people who have…
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How the brain transfers and stores information, such as the meaning of everyday sounds, remains largely unknown. New research from The Florey Institute of Neuroscience and Mental Health has shed light on the process, identifying a key brain pathway that links short-term learning to longer-term memory storage. The research could help guide future studies into disorders of memory such as…
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Dr Ming Soh is a Research Fellow in The Florey's Neurophysiology of Excitable Networks Group. She studies Sudden Unexpected Death in Epilepsy (SUDEP), which remains one of the most devasting and least understood risks for people living with epilepsy. In this Q&A, Dr Soh explains what SUDEP is and how The Florey's world-leading research is working to better understand and ultimately prevent…
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It is with deep sadness that The Florey mourns the passing of FightMND co-founder and former Australian of the Year, Neale Daniher AO. Neale was an extraordinary ambassador and tireless advocate in the fight against “the Beast” that is motor neurone disease (MND), which he courageously lived with for more than a decade. Through his powerful advocacy work, Neale helped to raise millions of…
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