Modulating metals homeostasis to treat neurodegenerative and psychiatric disorders
Similar to other neurodenerative disorders such as Alzheimer's disease, iron levels seem to be increased in Huntington’s disease (HD).
We hypothesise that reducing iron level will slow down the progression of the disease and correct cellular/molecular dysfunctions within key brain regions.
Notably, dysregulations in metals homeostasis have also been reported in psychiatric disorders, including schizophrenia and depression.
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