Ion Channels and Human Diseases Laboratory
Our research focuses on understanding the pathology of ion channel disorders, in particular epilepsy, using in vitro and in vivo models to reveal opportunities for developing novel therapies.
We use a multidisciplinary approach spanning ion channel biophysics, mouse transgenesis, genetic analysis, computational modeling and in vitro and in vivo electrophysiology.
Our research at a glimpse
- Functional characterization of epilepsy-causing mutations
- Multiphoton imaging of patient-derived induced pluripotent stem cell-derived brainoids
- Optogenetic modulation of the area tempestas – an epilepsy hot spot
- MRI tractography in mouse models of genetic epilepsy: Creation of prognostic and diagnostic structural biomarkers
- In vivo electrophysiological analysis in mouse models of genetic epilepsy
- High density multi-electrode array recording of in vitro networks in epilepsy
- High content automated analysis of ion channels in epilepsy
- Projects in network analysis of genetic epilepsy
- Multi-site patch clamp recording of cortical micro networks
- Neuroanatomical determinants of susceptibility in a model of genetic epilepsy
- “CLARITY” based glass brain imaging in health and disease
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