Optogenetic modulation of the area tempestas – an epilepsy hot spot

Several lines of study have recently converged to reveal a new target for controlling epileptic seizures.

Early work by Piredda and Gale (Nature 1985, 317:623) provided unequivocal evidence that the prepiriform cortex, subsequently coined the “area tempestas”, was a hot spot for initiation and spread of epileptic seizures.  Within this region a population of specialised inhibitory neurons called neurogliaform cells (NG) shows a stereotypic pattern of firing that implicates them seizures.


  • Examine real time modulation of the control of seizures.
  • Develop a role for the in vivo function of NG cells.
  • Explore the potential utility of NG cells in seizure expression.

In this project the candidate will use in vivo electrophysiological recording and optogenetic stimulation to achieve the aims.

Contact us

If you’re interested in learning more about this project please contact our team.

Please enter your first name
Please enter your last name
Please enter a valid phone number
Please enter a correct email address
Please provide information regarding your enquiry