Rebuilding the brain after stroke

Pluripotent stem cells can be used to generate a wide variety of neuronal subtypes relevant for repair of the central nervous system.

Recently we showed that cortical neurons can be transplanted into the part of the cortex damaged by a focal stroke and have a remarkable capacity to integrate into the existing host circuitry in order to restore motor function.

Aim

  • Explore whether we can restore multiple circuits in more severe models of stroke affecting multiple brain region by transplanting multiple neuronal cell types.

The project will utilise a number of in vitro and in vivo techniques including:

  • human pluripotent cell culture
  • immunochemistry
  • stereotaxic surgery
  • analysis of animal behaviour
  • histology and microscopy

Research team

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Student applications

Students who are applying to study at The Florey can register their interest in this project. Refer to our step-by-step guide to help you with your application

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Accepting students

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