Clinical Translation
We are investigating changes in the brain associated with different epilepsy phenotypes using various neuroimaging techniques.
These techniques include magnetic resonance imaging (MRI), functional MRI (fMRI), diffusion MRI, Positron Emission Tomography (PET), transcranial magnetic stimulation (TMS) and simultaneous electroencephalography (EEG) + fMRI. We apply our research findings together with current best practice clinical knowledge to improve clinical outcomes for individual patients, in collaboration with the Austin Hospital’s Comprehensive Epilepsy Program (CEP).
Sethi, M., Pedersen, M., Jackson, G.D., 2016. Polymicrogyric Cortex may Predispose to Seizures via Abnormal Network Topology: An fMRI Connectomics Study. Epilepsia 57, e64–e68. doi:10.1111/epi.13304
Newham, B.J.C., Curwood, E.K., Jackson, G.D., Archer, J.S., 2016. Pontine and cerebral atrophy in Lennox–Gastaut syndrome. Epilepsy Research 120, 98–103. doi:10.1016/j.eplepsyres.2015.12.005
Warren, A.E.L., Abbott, D.F., Vaughan, D.N., Jackson, G.D., Archer, J.S., 2016. Abnormal cognitive network interactions in Lennox-Gastaut syndrome: A potential mechanism of epileptic encephalopathy. Epilepsia 57, 812–822. doi:10.1111/epi.13342
Omidvarnia, A., Pedersen, M., Walz, J.M., Vaughan, D.N., Abbott, D.F., Jackson, G.D., 2016. Dynamic regional phase synchrony (DRePS). Hum. Brain Mapp. 37, 1970–1985. doi:10.1002/hbm.23151
Harvey, A.S., Mandelstam, S.A., Maixner, W.J., Leventer, R.J., Semmelroch, M., MacGregor, D., Kalnins, R.M., Perchyonok, Y., Fitt, G.J., Barton, S., Kean, M.J., Fabinyi, G.C.A., Jackson, G.D., 2015. The surgically remediable syndrome of epilepsy associated with bottom-of-sulcus dysplasia. Neurology 84, 2021–2028. doi:10.1212/WNL.0000000000001591
Pedersen, M., Curwood, E.K., Vaughan, D.N., Omidvarnia, A.H., Jackson, G.D., 2015. Abnormal Brain Areas Common to the Focal Epilepsies: Multivariate Pattern Analysis of fMRI. Brain Connectivity 6, 208–215. doi:10.1089/brain.2015.0367
Raffelt, D.A., Smith, R.E., Ridgway, G.R., Tournier, J.-D., Vaughan, D.N., Rose, S., Henderson, R., Connelly, A., 2015. Connectivity-based fixel enhancement: Whole-brain statistical analysis of diffusion MRI measures in the presence of crossing fibres. NeuroImage 117, 40–55. doi:10.1016/j.neuroimage.2015.05.039
Curwood, E.K., Pedersen, M., Carney, P.W., Berg, A.T., Abbott, D.F., Jackson, G.D., 2015. Abnormal cortical thickness connectivity persists in childhood absence epilepsy. Annals of Clinical and Translational Neurology 2, 456–464. doi:10.1002/acn3.178
Vaughan, D.N., Jackson, G.D., 2014. The Piriform Cortex and Human Focal Epilepsy. Frontiers in Neurology 5. doi:10.3389/fneur.2014.00259
Carney, P.W., Jackson, G.D., 2014. Insights into the Mechanisms of Absence Seizure Generation Provided by EEG with Functional MRI. Frontiers in Neurology 5. doi:10.3389/fneur.2014.00162
Carney, P.W., Harvey, A.S., Berkovic, S.F., Jackson, G.D., Scheffer, I.E., 2013. Siblings with refractory occipital epilepsy showing localized network activity on EEG-fMRI. Epilepsia 54, e28–e32. doi:10.1111/epi.12076
Carney, P.W., Masterton, R.A.J., Gill, D., Jackson, G.D., 2013. Nodular heterotopia and absence seizures: fMRI evidence that they may be connected. Epilepsy Research 106, 451–455. doi:10.1016/j.eplepsyres.2013.07.005
Masterton, R.A.J., Carney, P.W., Abbott, D.F., Jackson, G.D., 2013. Absence epilepsy subnetworks revealed by event-related independent components analysis of functional magnetic resonance imaging. Epilepsia 54, 801–808. doi:10.1111/epi.12163
Masterton, R.A., Carney, P.W., Jackson, G.D., 2012. Cortical and thalamic resting-state functional connectivity is altered in childhood absence epilepsy. Epilepsy Research 99, 327–334. doi:10.1016/j.eplepsyres.2011.12.014
Carney, P.W., Masterton, R.A., Flanagan, D., Berkovic, S.F., Jackson, G.D., 2012. The frontal lobe in absence epilepsy: EEG-fMRI findings. Neurology 78, 1157–1165.
Carney, P.W., Masterton, R.A., Harvey, A.S., Scheffer, I.E., Berkovic, S.F., Jackson, G.D., 2010. The core network in absence epilepsy: differences in cortical and thalamic BOLD response. Neurology 75, 904–911.
Research team
Supervisor
Member
Research group
Collaborators
Dr Saul Mullen
Dr Patrick Carney