Dr Gawain McColl

Laboratory head - Molecular Gerontology Laboratory

Dr Gawain McColl

PhD

I graduated with a PhD in Genetics from Monash University (1999), was a postdoctoral fellow at the University of Manchester (1999 to 2001) and then at the Buck Institute for Age Research (USA) in 2001, where I studied the genetics of ageing in C. elegans at with a Glenn Foundation/AFAR Fellowship awarded in 2003. In late 2007 I returned to Australia as a Research Fellow at the Mental Health Research Institute. I joined the Florey Faculty in 2013, where I am now Head of the Molecular Gerontology laboratory in the Neurodegeneration Division.

Research Papers

Showing 10 of 28. VIEW ALL

High-resolution complementary chemical imaging of bio-elements in Caenorhabditis elegans.
Year: 11/2015
Author(s): Hare DJ, Jones MW, Wimmer VC, Jenkins NL, de Jonge MD, Bush AI, McColl G
Author(s): Hare DJ, Jones MW, Wimmer VC, Jenkins NL, de Jonge MD, Bush AI, McColl G
Imaging metals in biology: balancing sensitivity, selectivity and spatial resolution.
Year: 10/2015
Author(s): Hare DJ, New EJ, de Jonge MD, McColl G
Author(s): Hare DJ, New EJ, de Jonge MD, McColl G
Stabilization of nontoxic Aβ-oligomers: insights into the mechanism of action of hydroxyquinolines in Alzheimer's disease.
Year: 02/2015
Author(s): Ryan TM, Roberts BR, McColl G, Hare DJ, Doble PA, Li QX, Lind M, Roberts AM, Mertens HD, Kirby N, Pham CL, Hinds MG, Adlard PA, Barnham KJ, Curtain CC, Masters CL
Author(s): Ryan TM, Roberts BR, McColl G, Hare DJ, Doble PA, Li QX, Lind M, Roberts AM, Mertens HD, Kirby N, Pham CL, Hinds MG, Adlard PA, Barnham KJ, Curtain CC, Masters CL
Accurate biometal quantification per individual Caenorhabditis elegans.
Year: 01/2016
Author(s): Ganio K, James SA, Hare DJ, Roberts BR, McColl G
Author(s): Ganio K, James SA, Hare DJ, Roberts BR, McColl G
Pro198Leu polymorphism affects the selenium status and GPx activity in response to Brazil nut intake.
Year: 12/2015
Author(s): Cardoso BR, Busse AL, Hare DJ, Cominetti C, Horst MA, McColl G, Magaldi RM, Jacob-Filho W, Cozzolino SM
Author(s): Cardoso BR, Busse AL, Hare DJ, Cominetti C, Horst MA, McColl G, Magaldi RM, Jacob-Filho W, Cozzolino SM
Direct in vivo imaging of ferrous iron dyshomeostasis in ageing Caenorhabditis elegans
Chemical Science
Year: 03/03/2015
Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging
Chemical Science
Year: 27/07/2015
Radiation Dose Limits for Bioanalytical X-ray Fluorescence Microscopy
Analytical Chemistry
Year: 21/11/2017
Author(s): Michael W. M. Jones, Dominic J. Hare, Simon A. James, Martin D. de Jonge, Gawain McColl
Author(s): Michael W. M. Jones, Dominic J. Hare, Simon A. James, Martin D. de Jonge, Gawain McColl
Simultaneous nanostructure and chemical imaging of intact whole nematodes
Chemical Communications
Year: 2019
Author(s): Michael W. M. Jones, Nicholas W. Phillips, Brian Abbey, Dominic J. Hare, Grant A. van Riessen, David J. Vine, Martin D. de Jonge, Gawain McColl
Author(s): Michael W. M. Jones, Nicholas W. Phillips, Brian Abbey, Dominic J. Hare, Grant A. van Riessen, David J. Vine, Martin D. de Jonge, Gawain McColl
Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans
eLife
Year: 21/07/2020
Author(s): Nicole L Jenkins, Simon A James, Agus Salim, Fransisca Sumardy, Terence P Speed, Marcus Conrad, Des R Richardson, Ashley I Bush, Gawain McColl
Author(s): Nicole L Jenkins, Simon A James, Agus Salim, Fransisca Sumardy, Terence P Speed, Marcus Conrad, Des R Richardson, Ashley I Bush, Gawain McColl
Caenorhabditis elegans: a model to investigate oxidative stress and metal dyshomeostasis in Parkinson's disease.
Year: 2014
Author(s): Chege PM, McColl G
Author(s): Chege PM, McColl G
Direct in vivo imaging of essential bioinorganics in Caenorhabditis elegans.
Year: 06/2013
Author(s): James SA, de Jonge MD, Howard DL, Bush AI, Paterson D, McColl G
Author(s): James SA, de Jonge MD, Howard DL, Bush AI, Paterson D, McColl G
Utility of an improved model of amyloid-beta (Aβ₁₋₄₂) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease.
Year: 2012
Author(s): McColl G, Roberts BR, Pukala TL, Kenche VB, Roberts CM, Link CD, Ryan TM, Masters CL, Barnham KJ, Bush AI, Cherny RA
Author(s): McColl G, Roberts BR, Pukala TL, Kenche VB, Roberts CM, Link CD, Ryan TM, Masters CL, Barnham KJ, Bush AI, Cherny RA
Caenorhabditis elegans maintains highly compartmentalized cellular distribution of metals and steep concentration gradients of manganese.
Year: 2012
Author(s): McColl G, James SA, Mayo S, Howard DL, Ryan CG, Kirkham R, Moorhead GF, Paterson D, de Jonge MD, Bush AI
Author(s): McColl G, James SA, Mayo S, Howard DL, Ryan CG, Kirkham R, Moorhead GF, Paterson D, de Jonge MD, Bush AI
PBT2 Reduces Toxicity in a C. elegans Model of polyQ Aggregation and Extends Lifespan, Reduces Striatal Atrophy and Improves Motor Performance in the R6/2 Mouse Model of Huntington's Disease.
Year: 2012
Author(s): Cherny RA, Ayton S, Finkelstein DI, Bush AI, McColl G, Massa SM
Author(s): Cherny RA, Ayton S, Finkelstein DI, Bush AI, McColl G, Massa SM
Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans.
Year: 07/2011
Author(s): Rogers AN, Chen D, McColl G, Czerwieniec G, Felkey K, Gibson BW, Hubbard A, Melov S, Lithgow GJ, Kapahi P
Author(s): Rogers AN, Chen D, McColl G, Czerwieniec G, Felkey K, Gibson BW, Hubbard A, Melov S, Lithgow GJ, Kapahi P
Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans.
Year: 09/2010
Author(s): McColl G, Rogers AN, Alavez S, Hubbard AE, Melov S, Link CD, Bush AI, Kapahi P, Lithgow GJ
Author(s): McColl G, Rogers AN, Alavez S, Hubbard AE, Melov S, Link CD, Bush AI, Kapahi P, Lithgow GJ
The Caenorhabditis elegans A beta 1-42 model of Alzheimer disease predominantly expresses A beta 3-42.
Year: 08/2009
Author(s): McColl G, Roberts BR, Gunn AP, Perez KA, Tew DJ, Masters CL, Barnham KJ, Cherny RA, Bush AI
Author(s): McColl G, Roberts BR, Gunn AP, Perez KA, Tew DJ, Masters CL, Barnham KJ, Cherny RA, Bush AI
Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans.
Year: 01/2008
Author(s): McColl G, Killilea DW, Hubbard AE, Vantipalli MC, Melov S, Lithgow GJ
Author(s): McColl G, Killilea DW, Hubbard AE, Vantipalli MC, Melov S, Lithgow GJ
An iron–dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta
Chemical Science
Year: 24/01/2014
The C. elegans ortholog of mammalian Ku70, interacts with insulin-like signaling to modulate stress resistance and life span.
Year: 10/2005
Author(s): McColl G, Vantipalli MC, Lithgow GJ
Author(s): McColl G, Vantipalli MC, Lithgow GJ
Fitness cost of extended lifespan in Caenorhabditis elegans.
Year: 12/2004
Author(s): Jenkins NL, McColl G, Lithgow GJ
Author(s): Jenkins NL, McColl G, Lithgow GJ
Heat shock protein accumulation is upregulated in a long-lived mutant of Caenorhabditis elegans.
Year: 07/2001
Author(s): Walker GA, White TM, McColl G, Jenkins NL, Babich S, Candido EP, Johnson TE, Lithgow GJ
Author(s): Walker GA, White TM, McColl G, Jenkins NL, Babich S, Candido EP, Johnson TE, Lithgow GJ
Testing evolutionary theories of aging.
Year: 06/2000
Author(s): McColl G, Jenkins NL, Walker DW, Lithgow GJ
Author(s): McColl G, Jenkins NL, Walker DW, Lithgow GJ
Evolution of lifespan in C. elegans.
Year: 05/2000
Author(s): Walker DW, McColl G, Jenkins NL, Harris J, Lithgow GJ
Author(s): Walker DW, McColl G, Jenkins NL, Harris J, Lithgow GJ
The Drosophila heat shock hsr-omega gene: an allele frequency cline detected by quantitative PCR.
Year: 11/1999
Author(s): McColl G, McKechnie SW
Author(s): McColl G, McKechnie SW
Both allelic variation and expression of nuclear and cytoplasmic transcripts of Hsr-omega are closely associated with thermal phenotype in Drosophila.
Year: 03/1998
Author(s): McKechnie SW, Halford MM, McColl G, Hoffmann AA
Author(s): McKechnie SW, Halford MM, McColl G, Hoffmann AA
Response of two heat shock genes to selection for knockdown heat resistance in Drosophila melanogaster.
Year: 08/1996
Author(s): McColl G, Hoffmann AA, McKechnie SW
Author(s): McColl G, Hoffmann AA, McKechnie SW

Showing 10 of 28. VIEW ALL

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