Neuropsychopharmacology.
Dr Burrows leads a team aiming to understand how genetic mutations found in complex brain conditions such as Autism Spectrum Disorder (ASD) and dementia can lead to altered brain connectivity and behavior across the lifespan.
Dr Burrows and her team use a touchscreen behavioural analysis that allows them to get an impressive readout of how mice solve problems, remember and pay attention. When mice perform the task correctly they receive a milkshake reward. These tasks are similar to the ones used by neuropsychologists to assess people. Her team’s work aims to bridge the translational divide between how we measure brain disorders in animals and in the clinic.
Her work has attracted significant funding and several awards, including a Victoria Fellowship (Veski, Victorian State Government) to train with pioneers with touchscreen rodent cognitive testing in Cambridge UK. She is an internationally recognised expert in touchscreen testing, has published work on behavioural phenotyping of mice modelling a range of brain disorders (including Autism Spectrum Disorder, Schizophrenia and Dementia), is invited to speak about her work to a wide range of audiences and has supervised >10 graduate students and mentors many early career researchers.
Dr Burrows believes that researchers from different disciplines will find innovative solutions to complex problems in science. Embodying this, she has recently lead a team of neuroscientists, software engineers and psychologists in successfully reverse translating a task from the clinic to assess attention in mice. This major advancement now makes it possible to investigate attention orienting deficits in mice using a task directly translatable to human clinical studies. An important innovation of our work is to train the mice to voluntarily head fix at the centre of the touchscreen until the presentation of the target after a cue, which is critical to allow mice to process the cues before responding to targets. This voluntary head fixing behaviour helps to control the starting position of the mice in each trial to obtain accurate measurements of whole-body response times. Response times are the main clinical outcome measurement for assessment of attention and cognitive domains, and the ability to measure this in mice is critical for translation.
Emma champions change in the research sector by implementing wide-reaching strategies that increase diversity and inclusion. She is a board director of Women in STEMM Australia, co-founding member of Women in Science Parkville Precinct and past chair of The Florey Equality in Science committee. Emma tweets all things science @embws.
Research Papers
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Environmental Enrichment Ameliorates Behavioral Impairments Modeling Schizophrenia in Mice Lacking Metabotropic Glutamate Receptor 5.
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Transgenic Mouse Models as Tools for Understanding How Increased Cognitive and Physical Stimulation Can Improve Cognition in Alzheimer's Disease.Brain plasticity (Amsterdam, Netherlands)
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Touchscreen testing reveals clinically relevant cognitive abnormalities in a mouse model of schizophrenia lacking metabotropic glutamate receptor 5.Scientific reports
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Social Isolation Alters Social and Mating Behavior in the R451C Neuroligin Mouse Model of Autism.Neural Plasticity
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Translational Assays for Assessment of Cognition in Rodent Models of Alzheimer's Disease and Dementia.Journal of molecular neuroscience : MN
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Cognitive endophenotypes, gene-environment interactions and experience-dependent plasticity in animal models of schizophrenia.Biological psychology
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A neuroligin-3 mutation implicated in autism causes abnormal aggression and increases repetitive behavior in mice.Molecular autism
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Decreased expression of mGluR5 within the dorsolateral prefrontal cortex in autism and increased microglial number in mGluR5 knockout mice: Pathophysiological and neurobehavioral implications.Brain, behavior, and immunity
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Evaluation of attention in APP/PS1 mice shows impulsive and compulsive behavioursGenes, Brain and Behavior
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Progressive impairments in executive function in the APP/PS1 model of Alzheimer’s disease as measured by translatable touchscreen testing
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