Cerebral Cortex
Laboratory head - Motor Neurone Disease Laboratory
Associate Professor Bradley Turner
BSc (Hons), PhD (Melb)
A/Prof. Bradley Turner is a NHMRC Dementia Research Leadership Fellow and Head of the Motor Neuron Disease Laboratory. He is a molecular neurobiologist who obtained his PhD in biochemistry at the University of Melbourne in 2005 and trained with Prof. Kay Davies and Prof. Kevin Talbot at the University of Oxford in mouse functional genetics as a NHMRC CJ Martin Fellow for 3 years. He was recruited back to the Florey Institute where he established the MND Laboratory supported by a Stafford Fox Senior Research Fellowship.
He has broad interest in modelling neurodegenerative diseases affecting the motor system using patient stem cell and animal models, spanning pediatric and adult motor neuron diseases. He is a member of the National Health and Medical Research Council Grant Review Panels, Assigners Academy and MND Australia Research Committee.
Key collaborators:
Prof. Kevin Talbot, University of Oxford
Prof. Kay Davies, University of Oxford
Prof. Jean-Philippe Loeffler, University of Strasbourg
Prof. Michael Spedding, Spedding Research Services, Paris
Dr Severine Boillee, Brain and Spine Institute, Paris
Prof. Neil Cashman, University of British Columbia
Prof. Uri Saragovi, McGill University
Prof. Steve Vucic, University of Sydney
A/Prof. Alice Pebay, Centre for Eye Research Australia,
Dr Shyuan Ngo, University of Queensland
Dr Mary-Louise Rogers, Flinders University
A/Prof. Paul Gregorevic, University of Melbourne
Awards and achievements
NHMRC Dementia Research Leadership Fellowship, 2018
Stafford Fox Senior Research Fellowship, 2015
Inaugural Bethlehem Griffiths Research Foundation Young Researcher of the Year Prize, 2010
Research Papers
Showing 10 of 57. VIEW ALL
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Synapse Dysfunction of Layer v Pyramidal Neurons Precedes Neurodegeneration in a Mouse Model of TDP-43 Proteinopathies
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Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent PathwaysCellular and Molecular Neurobiology
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AMPK Signalling and Defective Energy Metabolism in Amyotrophic Lateral SclerosisNeurochemical Research
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Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 miceHuman Molecular Genetics
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Inhibition of motor neuron death in vitro and in vivo by a p75 neurotrophin receptor intracellular domain fragmentJournal of Cell Science
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Combination of valproic acid and morpholino splice-switching oligonucleotide produces improved outcomes in spinal muscular atrophy patient-derived fibroblastsNeurochemistry International
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Rilmenidine promotes MTOR-independent autophagy in the mutant SOD1 mouse model of amyotrophic lateral sclerosis without slowing disease progressionAutophagy
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Emerging therapies and challenges in spinal muscular atrophyAnnals of Neurology
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TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathwayHuman Molecular Genetics
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Glutathione monoethyl ester prevents TDP-43 pathology in motor neuronal NSC-34 cellsNeurochemistry International
Showing 10 of 57. VIEW ALL
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