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AVERT | International stroke rehabilitation database available for research projects

The study investigators consider that A Very Early Rehabilitation Trial (AVERT) provides a large international stroke rehabilitation database and is an important resource for ongoing research.

The database has potential uses of the data extending beyond the AVERT Statistical Analysis Plan and Economic Evaluation Plan.

What is AVERT?

AVERT is an international trial focussed on commencing frequent, higher dose, mobilisation within 24 hours of stroke and compared to usual stroke unit care (Lancet 2015). The study was a parallel-group, single blind, randomised controlled trial. 2104 patients were recruited between July 2006 and October 2014 from 56 acute stroke units in Australia, New Zealand, Singapore, Malaysia and the United Kingdom. Data collected included: stroke screening, baseline demographic and mobilisation intervention. Three and 12 month outcomes included disability, mobility, health related quality of life, mood, cognition and costs. Serious and non-serious adverse events were collected.  The trial protocol is available to download. The trial is registered with the Australian New Zealand Clinical Trials Registry, number ACTRN12606000185561.

Project Proposals

The study investigators encourage and solicit project proposals with the aim to publication. There are Procedures and Processes in place to permit access to study data for project analysis and publication through a review and approval process under the governance of the AVERT Management Committee. Under these Procedures and Processes, any investigator at any University or Research Institute can propose a project. When approved, one or more members of the AVERT management committee will be nominated as a co-investigator/s and collaborate on the project.

 

If you are interested in accessing the AVERT database, please familiarise yourself with the Procedures and Processes and data collected. Then complete and submit an Expression of Interest Form and a two page summary Curriculum Vittae to avert@florey.edu.au.

Trial Publications

The AVERT Trial Collaboration group, Bernhardt J, Langhorne P, Lindley RI, Thrift AG, Ellery F, Collier J, Churilov L, Moodie M, Dewey H, Donnan G. Efficacy and safety of very early mobilisation within 24 h of stroke onset (AVERT): a randomised controlled trial. Lancet. 2015; 386: 46-55. doi: 10.1016/S0140-6736(15)60690-0

Rethnam V, Bernhardt J, Dewey H, Moodie M, Johns H, Gao L, Collier J, Ellery F, Churilov L, on behalf of AVERT Trial Collaboration group. Utility-weighted modified Rankin Scale: still too crude to be a truly patient-centric primary outcome measure? Int J Stroke. 2019: 1-10. doi: https://doi.org/10.1177/1747493019830583

Gao L, Sheppard L, Wu O, Churilov L, Mohebbi M, Collier J, Bernhardt J, Ellery F, Dewey H, Moodie M, The AVERT Trial Collaboration group. Economic evaluation of a phase III randomised controlled trial of very early mobilisation after stroke (AVERT). BMJ Open. 2019; 9: e026230. doi: 10.1136/bmjopen-2018-026230

Cumming TB, Bernhardt J, Lowe D, Collier J, Dewey H, Langhorne P, Thrift AG, Green A, Mohanraj R, Kramer SF, Churilov L, Linden T, and on behalf of the AVERT Trial Collaboration group. Early mobilization after stroke is not associated with cognitive outcome. Findings from AVERT Stroke. 2018; 49: 2147-2154. doi: 10.1161/STROKEAHA.118.022217

Langhorne P, Wu O, Rodgers H, Ashburn A, Bernhardt J. A Very Early Rehabilitation Trial after stroke (AVERT): a phase III, multicentre, randomised controlled trial. Health Technology Assessment. 2017; 21: 1-120. doi: 10.3310/hta21540

Sheppard L, Dewey H, Bernhardt J, Collier JM, Ellery F, Churilov L, Tay-Teo K, Wu O, Moodie M, on behalf of the AVERT Trial Collaboration Group. Economic Evaluation Plan (EEP) for A Very Early Rehabilitation Trial (AVERT): An international trial to compare the costs and cost-effectiveness of commencing out of bed standing and walking training (very early mobilization) within 24 hours of stroke onset with usual stroke unit care. Int J Stroke. 2016; 11: 492-494. doi: 10.1177/1747493016632254

Bernhardt J, Churilov L, Ellery F, Collier J, Chamberlain J, Langhorne P, Lindley RI, Moodie M, Dewey H, Thrift AG, Donnan G, on behalf of the AVERT Collaboration Group. Pre-specified dose-response analysis for A Very Early Rehabilitation Trial (AVERT). Neurology. 2016; 86: 2138-2145. doi: 10.1212/WNL.0000000000002459

Bernhardt J, Raffelt A, Churilov L, Lindley RI, Speare S, Ancliffe J, Katijjahbe MA, Hameed S, Lennon S, McRae A, Tan D, Quiney J, Williamson HC, Collier J, Dewey HM, Donnan GA, Langhorne P, Thrift AG, on behalf of the AVERT Trialists' Collaboration. Exploring threats to generalisability in a large international rehabilitation trial (AVERT). BMJ Open. 2015; 5: e008378. doi: 10.1136/bmjopen-2015-008378

Bernhardt J, Lindley RI, Lalor E, Ellery F, Chamberlain J, Van Holsteyn J, Collier JM, Dewey HM, Parsons B, Moodie M, Lennon S, Donnan GA, Thrift AG, Churilov A, Langhorne P, on behalf of the AVERT Collaboration Group. AVERT2 (a very early rehabilitation trial, a very effective reproductive trigger): retrospective observational analysis of the number of babies born to trial staff. BMJ. 2015; 351: h6432. doi: 10.1136/bmj.h6432. doi: 10.1136/bmj.h6432

Bernhardt J, Churilov L, Dewey H, Lindley R, Moodie M, Collier J, Langhorne P, Thrift A, Donnan G, for the AVERT Collaborators. Statistical Analysis Plan (SAP) for A Very Early Rehabilitation Trial (AVERT): An international trial to determine the efficacy and safety of commencing out of bed standing and walking training (very early mobilisation) within 24 h of stroke onset vs usual stroke unit care. Int J Stroke. 2015; 10: 23-24. doi: 10.1111/ijs.12423

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