Dr Darius Lane
PhD

Dr Darius Lane is a Senior Research Officer working across The Florey’s Translational Neurodegeneration Group and Translational Cardiovascular and Renal Research Group, within the Dementia and Stroke and Critical Care Priority Research Areas. A biochemist and molecular biologist, he investigates how oxidative stress, iron dysregulation, ferroptosis, mitochondrial dysfunction and impaired cellular metabolism contribute to neurological and systemic disease.

Darius completed his PhD at Monash University, examining the interplay between ascorbate and iron in cancer, before undertaking postdoctoral research at the University of Sydney on iron and ascorbate metabolism, redox biology and therapeutic development. His achievements have been recognised through an NHMRC Peter Doherty Fellowship, a Cancer Institute NSW Early Career Fellowship and selection as an inaugural AMP Tomorrow Maker.

His current research bridges fundamental biochemistry, cellular and molecular biology, preclinical physiology and translational critical care. Major programs include defining ferroptotic and metabolic mechanisms of neuronal injury in Alzheimer’s disease, and elucidating how megadose sodium ascorbate reverses brain, cardiovascular and kidney dysfunction in sepsis. He has authored more than 80 peer-reviewed publications, with 87 outputs indexed in Web of Science, more than 10,700 citations and an h-index of 39.