Understanding the role of metals in normal and pathological ageing

The project will use a variety of techniques, such as in vivo mouse models (animal behavior, surgery, microdialysis, controlled cortical impact TBI model etc), multielectrode arrays (for high throughput electrophysiology), cell culture (primary cultures, cell lines, microfluidic cultures), synaptic RNA profiling using next generation sequencing and other more standard methodologies such as western blot and histological work (stereological analysis using both animal and human tissues) to explore the basic biology and to also address potential therapeutic applications in these conditions.