T2 relaxometry is a quantitative MR imaging modality that provides an estimate of the T2 relaxation constant of the imaged tissue.
T2 can be altered due to cell damage, with increased T2 relaxation time arising from higher fluid content and potential pathology in the brain in both grey and white matter. Regional T2-relaxometry has been used for many years in the assessment of hippocampal sclerosis at advanced epilepsy imaging centres including here at the Florey. Our team has also developed analysis methods that allow whole-brain T2 maps to be assessed across the entire brain at millimetre spatial resolution.
Abbott DF, Pell GS, Pardoe HR, Jackson GD. Selecting appropriate voxel-based methods for neuroimaging studies. NeuroImage 59(2)885–886 (2012).
Abbott DF, Pell GS, Pardoe H, Jackson GD. Voxel-Based Iterative Sensitivity (VBIS) analysis: methods and a validation of intensity scaling for T2-weighted imaging of hippocampal sclerosis. NeuroImage 44(3):812-819 (2009).
Pell GS, Briellmann RS, Pardoe HR, Abbott DF, and Jackson GD. Composite voxel-based analysis of volume and T2 relaxometry in temporal lobe epilepsy. NeuroImage 39(3): 1151-1161 (2008).
Pell GS, Briellmann RS, Waites AB, Abbott DF, Lewis DP and Jackson GD. Optimized clinical T2 relaxometry with a standard CPMG sequence. J Magn Reson Imaging 23(2):248-52 (2006).
Pell GS, Briellmann RS, Waites AB, Abbott DF, Jackson GD. Voxel-Based Relaxometry: A new approach for analysis of T2 relaxometry changes in epilepsy. NeuroImage 21(2):707-713 (2004).