Modulating metals homeostasis to treat neurodegenerative and psychiatric disorders
Similar to other neurodegenerative disorders such as Alzheimer’s disease, iron levels seem to be increased in Huntington’s disease (HD). Notably, dysregulations in metal homeostasis have also been reported in psychiatric disorders, including schizophrenia and depression.
Aims
- Test the hypothesis that reducing iron levels in Huntington’s disease (HD) will slow down the disease progression and correct cellular/molecular dysfunctions within key brain regions.
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