Developing H2 relaxin analog – B7-33 – as antifibrotic therapy
Fibrosis (tissue scarring) results from an aberrant wound-healing response to organ injury and contributes to organ dysfunction and failure through excessive extracellular matrix (primarily collagen) build-up in fibrosis and fibrosis-related diseases (e.g., heart, kidney failure). These are unmet medical problems that contribute to more than 45% of deaths globally. Currently, available therapies (e.g., ACE inhibitors, ARBs) only delay disease progression by months and can induce severe side effects after chronic administration. Novel anti-fibrotic therapies that are safe and can renormalise organ function are needed.
We’ll produce relaxin hormone-based peptides analogues that are shown to have strong anti-fibrotic effects. Using modern solid-phase peptide synthesis (SPPS), rational and structure-based design, we’ll develop drug candidates. The preclinical analogues will be tested in cell-based assays (RXFP1 cells, binding, and cAMP potency) and in animal models of fibrosis.
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Students who are applying to study at The Florey can register their interest in this project. Refer to our step-by-step guide to help you with your application.