The team’s work opens new pathways to investigate and advance therapeutic options in MSA that target iron overload in the brain.
Led by Dr Jay Shukla, Prof David Finkelstein and team, new research published in the journal Neurobiology of Disease marks the first study to demonstrate elevated brain iron levels in mice with MSA.
“Using a research model, we were able to target and reduce brain iron levels using a known iron-lowering compound. Excitingly, our results showed that the compound slowed neurodegeneration and prevented symptom progression in mice giving us confidence that we’re on the right track in understanding more about treating this disease,” said Dr Shukla.
While scientists have identified high levels of brain iron in people affected by Multiple System Atrophy through post-mortem studies, the role of iron in disease progression and the question of whether reducing iron levels could help improve MSA disease symptoms has remained unanswered.
“What we believe may be contributing to elevated brain iron levels in Multiple System Atrophy is dysfunction of an enzyme that plays a role in the body’s iron metabolism. Targeting this enzyme and accumulated iron stores may prove a viable therapeutic strategy,” Dr Shukla explained.
Multiple System Atrophy is a degenerative, parkinsonian condition affecting movement, breathing, blood pressure and other body functions. Around 3,000 people in Australia live with the condition.
No disease-modifying therapies are currently available to treat the condition. The average prognosis after receiving a diagnosis of MSA is currently less than ten years, hence treatment options are desperately needed.
“For people living with Multiple System Atrophy and their families and carers, we hope this research and the work we are continuing to do in MSA at The Florey Institute sends a message of hope,” said Professor Finkelstein, Head of the Parkinson’s Disease Laboratory at the Florey Institute.
“We are constantly making progress in learning more about this rare disorder and working to find new treatment pathways to improve the lives of those who are affected,” he added.
“This exciting project by the team at Florey Institute is a great example of the excellent work supported by the Multiple System Atrophy Coalition’s research grant program. Given our goal to seed fund the development of disease-modifying therapies which can slow, stop or reverse the progression of MSA, the new evidence presented in this paper gives us hope that a successful therapeutic strategy for MSA may be in reach,” commented Pam Bower, Board of Directors from The Multiple System Atrophy Coalition.
The research was made possible by funding received from The Multiple System Atrophy Coalition USA and the Austrian Science Fund.
The study has been published in Neurobiology of Disease: doi.org/10.1016/j.nbd.2021.105509.
Comparison of accumulated iron in the brain of an MSA animal model (left) and a normal animal model (right) where the black stain in both images represents iron positive structures.
