Illuminating the wonders of the brain

Research at The Florey is geared at unravelling the complexities of neural circuits, studying neurodevelopmental processes, investigating disease mechanisms, and exploring potential therapeutic strategies for neurological disorders.

Microscopy techniques play a critical role in advancing our understanding of the brain’s structure and function. The Neuropix Imaging competition highlights these research efforts through a microscopic lens.

We hope to inspire the next generation of researchers through the power of imaging.

Young male researcher works at a Florey microscope. A computer screen in the background shows a vivid red microscopy image.

Neuropix People's Choice Award

The 2024 Neuropix People’s Choice Award is open to the public for voting on Monday 5 August. The image with the most number of votes will be crowned Neuropix People’s Choice!

Stay tuned for more information here and on our social media channels.

2023 winners

Sparkling Pink Heart

Scientific Award – Shivani Vaidya, Addiction Neuroscience Group

Captured on an LSM 900 confocal microscope, this combined image depicts two different hemispheres of the medial habenula.

The cell nucleus (pink) is surrounded by VGLUT1 mRNA (white).

Sparkling Pink Heart – microscopy image

Wysteria Joy

People’s Choice Award – Chau Tran, Personalised Therapeutics Group

Using a Zeiss LSM 900 microscope, this image shows surviving motor neurons from patients with motor neurone disease in mouse brains after 6 months.

Lower motor neurons are labelled with CHAT (green) and purple 8-OHG, biomarker of oxidative stress.

Florey microscopes and imaging tools
Wisteria Joy – Florey microscopy imagery

2023 entrants

Synaptic transmission in brain organoids – Florey microscopy imagery
Synaptic transmission in brain organoids

Pamela Kairath (PhD), Research Fellow

Brain organoids neurons, VGlut1, vglumate transporter 1 in pink, nuclei in blue and tubulin β3 in yellow.

Overview of a spinal cord organoid – Florey microscopy imagery
Overview of a spinal cord organoid

Lijun Loh, PhD student

Motor neurons in green and neurofilaments in red.

A neuromuscular organoid – Florey microscopy imagery
A neuromuscular organoid

Nirma Perera (PhD), Senior Research Officer

MND patient stem cell-derived organoid shows red nerve cells, blue nuclei and green autophagy protein.

Bright cells meeting at the river of the ventricle – Florey microscopy imagery
Bright cells meeting at the river of the ventricle

Alexandra Fraser, MPhil student

Stress marker c-fos in green and nuclei (blue) in a brain exposed to Porsolt test.

Jackson Pollock (reborn) – Florey microscopy imagery
Jackson Pollock (reborn)

Francois-Xavier Beau, PhD student

Human lab-grown ‘mini-brain’. Oligodendrocytes (immature in green and mature in orange) can be seen doing their own thing (myelin in red), nuclei in blue.

Can trapped drugs escape blood vessels to reach neurons? – Florey microscopy imagery
Breaking Barriers: Novel peptide-linked drugs penetrate the blood-brain barrier

Azin Amin (PhD), Research Fellow

The successful journey of drugs conjugated to a novel peptide (magenta) as they traverse the blood-brain barrier, escaping blood vessels (green) to reach the neurons (red) within the brain. Astrocytes in yellow and nuclei blue.

Microscopic biological sword – Florey microscopy imagery
Microscopic biological sword

Hannah Truong (PhD), Postdoctoral Research Officer

Live adult C.elegans worms fed with GFP tagged Ferritin (FTN-2:GFP) and mounted onto glass slide. Head and body image was captured by SP8 confocal microscope equipped with 20x optical lens.

OH MY oliGODendrocyte! – Florey microscopy imagery
OH MY oliGODendrocyte!

Katherine (Katie) Lewis, PhD student

Oligodendroglia are the myelinating cells and are essential for maintaining brain health. Nuclei (blue), PDGFR⍺ (green; stains for oligodendrocyte precursor cells), EdU (magenta; marks cell proliferation).

Our microscopy services

The Florey Microscopy Facility supports in-house scientists and visitors in using advanced light microscopy methods for their research.

The facility houses a collection of state-of-the-art microscopy equipment and image processing tools. The experienced microscopy team are also available to assist users throughout the entire process of microscopic imaging.

Learn more
Close up of a microscope, showing the eyepiece and blurred imagery on a computer screen in the background.