Sleep and Cognition Group
Our research focuses on the role of sleep in memory, mood, emotion and neurodegenerative disease.
Current work investigates the neurobiology of the neuropeptide orexin on sleep, in particular the influences of orexin receptor antagonists on sleep quality and subsequent performance in tests of memory and emotion in animal models. This work expands into investigations of the role of the orexin system in Alzheimer’s disease and frontotemporal dementia, and explores the potential of orexin receptor antagonists to modulate disease progression in mouse models of these diseases.
Research interests
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Techniques
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Research team
Research team head
Associate Professor Laura Jacobson
Group Head
Team members
Dr Giancarlo Allocca
Research Fellow
Professor Emeritus Daniel Hoyer
Research Fellow
Dr Ryan Keenan
Research Fellow
Research and technical staff
- Heather Daykin
PhD students
- Jarrah Kron
- Anne-Marie Peeters
- Yasmin Potts
Selected publications
- Jacobson LH, Hoyer D and Lecea L (2022), ‘Hypocretins (orexins): The ultimate translational neuropeptides’, Journal of Internal Medicine, 291(5):533–556, doi:10.1111/joim.13406
- Jacobson LH and Hoyer D (2022), ‘Losing sleep with age’, Science, 375(6583):816–817, doi:10.1126/science.abo1822
- Hoyer D, Allen A and Jacobson LH (2020), ‘Hypnotics with novel modes of action’, British Journal of Clinical Pharmacology, 86(2):244–249, doi:10.1111/bcp.14180
Contact us
For more information about our group’s research you can contact us by submitting this form.
