Understanding the biology of MS using iPSC-derived organoids
Multiple sclerosis (MS) is characterised by sporadic autoimmune attacks on myelin, the lipid-dense sheath that encases neuronal axons.
To date, no drugs that have been identified in mouse models of MS to promote repair and regeneration of this myelin sheath have translated through to clinical use.
This highlights the need for improved model systems for biological interrogation into these processes, as well as for drug screening.
Aim
- To investigate if peripheral monocytes help or hinder remyelination and repair.
In our laboratory we use human induced pluripotent stem cells (iPSC) to generate 3D organoids.
We have successfully used these organoids to create a humanised model of multiple sclerosis characterised by demyelination, microglial activation and phagocytosis of myelin, and remyelination.
We know in MS that there is peripheral immune cell infiltration into the central nervous system during demyelinating attacks.
Using MS patient blood samples, we aim to isolate monocytes and seed them into our MS organoid model to interrogate whether the peripheral monocytes help or hinder remyelination and repair.
Research team
Research group
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