Rebuilding the brain after stroke
Pluripotent stem cells can be used to generate a wide variety of neuronal subtypes relevant for repair of the central nervous system.
Recently we showed that cortical neurons can be transplanted into the part of the cortex damaged by a focal stroke and have a remarkable capacity to integrate into the existing host circuitry in order to restore motor function.
Aim
- Explore whether we can restore multiple circuits in more severe models of stroke affecting multiple brain region by transplanting multiple neuronal cell types.
The project will utilise a number of in vitro and in vivo techniques including:
- human pluripotent cell culture
- immunochemistry
- stereotaxic surgery
- analysis of animal behaviour
- histology and microscopy
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