Metallomics
After competing his MSc at Fujian Normal University, China in 1985, Dr Xiao worked there for four years as a faculty member teaching Inorganic Chemistry at all levels. In 1989, he took up a scholarship offer from La Trobe University in Australia to undertake a postgraduate study on modelling the chemistry of molybdenum enzymes under the supervision of Prof. Anthony Wedd and obtained his PhD in chemistry in 1993. He then moved to the University of Melbourne as a Post-doc (1993-1999) and as a Research Fellow and Research Group Leader (2000-2016) to work in the area of metal-containing proteins and enzymes, especially those containing Cu, Zn and Fe.
In 2017, he joined the Florey Institute of Neuroscience and Mental Health as a Senior Research Fellow, Florey Faculty and Lab Head of Neurochemistry of Metal Ions, while also maintained his connection to the Bio21 Molecular Science and Biotechnology Institute and School of Chemistry at the University of Melbourne. His research area is the Chemistry of Metal Ions in Biology. His current research interests include molecular probes for bio-metals and molecular aspects of metallo-proteins and -enzymes that are important for metabolism of metal ions (Cu, Zn, Fe) in biological systems. Since 2000, he has supervised and co-supervised 6 Honours, 3 Masters and 15 PhD students.
He has published over 70 journal articles with 74% first and/or senior authorship and received total over 2,300 citations. He has presented invited lectures regularly at national and international conferences.
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Location
Florey Institute of Neuroscience and Mental Health
30 Royal Parade
Parkville
3052
Victoria
Australia
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Research teams
- Head ofNeurochemistry of Metal Ions
Research Papers
Showing 10 of 93. VIEW ALL
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Evaluation of Cu(i) binding to the E2 domain of the amyloid precursor protein – a lesson in quantification of metal binding to proteins via ligand competitionAuthor(s): Tessa R. Young, Anthony G. Wedd, Zhiguang Xiao
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Glutaredoxins employ parallel monothiol–dithiol mechanisms to catalyze thiol–disulfide exchanges with protein disulfidesChemical Science
- Year: 2018
Author(s): Ashwinie A. Ukuwela, Ashley I. Bush, Anthony G. Wedd, Zhiguang XiaoAuthor(s): Ashwinie A. Ukuwela, Ashley I. Bush, Anthony G. Wedd, Zhiguang Xiao -
The Human Amyloid Precursor Protein Binds Copper Ions Dominated by a Picomolar-Affinity Site in the Helix-Rich E2 DomainBiochemistry
- Volume: 57
- Page(s): 4165-4176
- Year: 2018
Author(s): Young, T.R., Pukala, T.L., Cappai, R., Wedd, A.G., Xiao, Z.Author(s): Young, T.R., Pukala, T.L., Cappai, R., Wedd, A.G., Xiao, Z. -
Evaluation of Cu(i) binding to the E2 domain of the amyloid precursor protein-a lesson in quantification of metal binding to proteins via ligand competitionMetallomics
- Volume: 10
- Page(s): 108-119
- Year: 2018
Author(s): Young, T.R., Wedd, A.G., Xiao, Z.Author(s): Young, T.R., Wedd, A.G., Xiao, Z. -
di-Cysteine motifs in the C-terminus of plant HMA4 proteins confer nanomolar affinity for zinc and are essential for HMA4 function in vivoJournal of experimental botany
- Volume: 69
- Page(s): 5547-5560
- Year: 2018
Author(s): Lekeux, G., Laurent, C., Joris, M., Jadoul, A., Jiang, D., Bosman, B., Carnol, M., Motte, P., Xiao, Z., Galleni, M., Hanikenne, M.Author(s): Lekeux, G., Laurent, C., Joris, M., Jadoul, A., Jiang, D., Bosman, B., Carnol, M., Motte, P., Xiao, Z., Galleni, M., Hanikenne, M. -
Glutaredoxins employ parallel monothiol-dithiol mechanisms to catalyze thiol-disulfide exchanges with protein disulfidesChemical Science
- Volume: 9
- Page(s): 1173-1183
- Year: 2018
Author(s): Ukuwela, A.A., Bush, A.I., Wedd, A.G., Xiao, Z.Author(s): Ukuwela, A.A., Bush, A.I., Wedd, A.G., Xiao, Z. -
Molecular Mechanisms of Glutaredoxin Enzymes: Versatile Hubs for Thiol–Disulfide Exchange between Protein Thiols and GlutathioneJournal of Molecular Biology
- Volume: 431
- Page(s): 158-177
- Year: 2019
Author(s): Xiao, Z., La Fontaine, S., Bush, A.I., Wedd, A.G.Author(s): Xiao, Z., La Fontaine, S., Bush, A.I., Wedd, A.G. -
The crystal structure of the CopC protein from Pseudomonas fluorescens reveals amended classifications for the CopC protein familyJournal of Inorganic Biochemistry
- Year: 06/2019
Author(s): Saumya R. Udagedara, Chathuri J.K. Wijekoon, Zhiguang Xiao, Anthony G. Wedd, Megan J. MaherAuthor(s): Saumya R. Udagedara, Chathuri J.K. Wijekoon, Zhiguang Xiao, Anthony G. Wedd, Megan J. Maher -
The Scs disulfide reductase system cooperates with the metallochaperone CueP in Salmonella copper resistanceJournal of Biological Chemistry
- Year: 01/11/2019
Author(s): Pramod Subedi, Jason J. Paxman, Geqing Wang, Ashwinie A. Ukuwela, Zhiguang Xiao, Begoña HerasAuthor(s): Pramod Subedi, Jason J. Paxman, Geqing Wang, Ashwinie A. Ukuwela, Zhiguang Xiao, Begoña Heras -
di-Cysteine Residues of the Arabidopsis thaliana HMA4 C-Terminus Are Only Partially Required for Cadmium TransportFrontiers in Plant Science
- Year: 26/05/2020
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CopC Protein fromPseudomonas fluorescensSBW25 Features a Conserved Novel High-Affinity Cu(II) Binding SiteInorganic Chemistry
- Year: 03/2015
Author(s): Chathuri J. K. Wijekoon, Tessa R. Young, Anthony G. Wedd, Zhiguang XiaoAuthor(s): Chathuri J. K. Wijekoon, Tessa R. Young, Anthony G. Wedd, Zhiguang Xiao -
Evaluation of employing poly-lysine tags versus poly-histidine tags for purification and characterization of recombinant copper-binding proteinsJournal of Inorganic Biochemistry
- Page(s): 286--294
- Year: 09/2016
Author(s): Chathuri J.K. Wijekoon, Ashwinie A. Ukuwela, Anthony G. Wedd, Zhiguang XiaoAuthor(s): Chathuri J.K. Wijekoon, Ashwinie A. Ukuwela, Anthony G. Wedd, Zhiguang Xiao -
Copper binding and redox chemistry of the Aβ16 peptide and its variants: insights into determinants of copper-dependent reactivityMetallomics
- Year: 2017
Author(s): Nineveh Yako, Tessa R. Young, Jade M. Cottam Jones, Craig A. Hutton, Anthony G. Wedd, Zhiguang XiaoAuthor(s): Nineveh Yako, Tessa R. Young, Jade M. Cottam Jones, Craig A. Hutton, Anthony G. Wedd, Zhiguang Xiao -
Copper ATPase CopA from Escherichia coli: Quantitative Correlation between ATPase Activity and Vectorial Copper TransportJournal of the American Chemical Society
- Year: 29/03/2017
Author(s): Chathuri J. K. Wijekoon, Saumya R. Udagedara, Roland L. Knorr, Rumiana Dimova, Anthony G. Wedd, Zhiguang XiaoAuthor(s): Chathuri J. K. Wijekoon, Saumya R. Udagedara, Roland L. Knorr, Rumiana Dimova, Anthony G. Wedd, Zhiguang Xiao -
Molecular Aspects of a Robust Assay for Ferroxidase Function of CeruloplasminInorganic Chemistry
- Year: 17/05/2017
Author(s): Laura Cortes, Blaine R. Roberts, Anthony G. Wedd, Zhiguang XiaoAuthor(s): Laura Cortes, Blaine R. Roberts, Anthony G. Wedd, Zhiguang Xiao -
Reduction potentials of protein disulfides and catalysis of glutathionylation and deglutathionylation by glutaredoxin enzymesBiochemical Journal
- Year: 09/11/2017
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Copper binding and redox chemistry of the Aβ16 peptide and its variants: insights into determinants of copper-dependent reactivityMetallomics
- Year: 2017
Author(s): Nineveh Yako, Tessa R. Young, Jade M. Cottam Jones, Craig A. Hutton, Anthony G. Wedd, Zhiguang XiaoAuthor(s): Nineveh Yako, Tessa R. Young, Jade M. Cottam Jones, Craig A. Hutton, Anthony G. Wedd, Zhiguang Xiao -
Reduction potentials of protein disulfides and catalysis of glutathionylation and deglutathionylation by glutaredoxin enzymesBiochemical Journal
- Volume: 474
- Page(s): 3799--3815
- Year: 09/2017
Author(s): Ashwinie A. Ukuwela, Ashley I. Bush, Anthony G. Wedd, Zhiguang XiaoAuthor(s): Ashwinie A. Ukuwela, Ashley I. Bush, Anthony G. Wedd, Zhiguang Xiao -
A set of robust fluorescent peptide probes for quantification of Cu(ii) binding affinities in the micromolar to femtomolar rangeMetallomics
- Volume: 7
- Page(s): 567-578
- Year: 2015
Author(s): Young, T.R., Wijekoon, C.J.K., Spyrou, B., Donnelly, P.S., Wedd, A.G., Xiao, Z.Author(s): Young, T.R., Wijekoon, C.J.K., Spyrou, B., Donnelly, P.S., Wedd, A.G., Xiao, Z. -
Metal binding to the N-terminal cytoplasmic domain of the P
IB ATPase HMA4 is required for metal transport in ArabidopsisPlant Molecular Biology- Volume: 90
- Page(s): 453-466
- Year: 2016
Author(s): Laurent, C., Lekeux, G., Ukuwela, A.A., Xiao, Z., Charlier, J.-B., Bosman, B., Carnol, M., Motte, P., Damblon, C., Galleni, M., Hanikenne, M.Author(s): Laurent, C., Lekeux, G., Ukuwela, A.A., Xiao, Z., Charlier, J.-B., Bosman, B., Carnol, M., Motte, P., Damblon, C., Galleni, M., Hanikenne, M. -
New Probes for Weaker Cu (I) Binding Sites Completes a Set of Four That Can Detect Affinities from Nanomolar to AttomolarJOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- Volume: 19
- Page(s): S133--S133
- Year: 2014
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PcoE-a metal sponge expressed to the periplasm of copper resistance E. coli. Implication of its function role in copper resistanceJOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- Volume: 19
- Page(s): S389--S389
- Year: 2014
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The functional roles of the three copper sites associated with the methionine-rich insert in the multicopper oxidase CueO from E. coliMetallomics
- Year: 2015
Author(s): Laura Cortes, Anthony G. Wedd, Zhiguang XiaoAuthor(s): Laura Cortes, Anthony G. Wedd, Zhiguang Xiao -
Glutaredoxin1 protects neuronal cells from copper-induced toxicityBioMetals
- Volume: 27
- Page(s): 661--672
- Year: 11/05/2014
Author(s): Michael A. Cater, Stephanie Materia, Zhiguang Xiao, Kamil Wolyniec, Susan M. Ackland, Yann W. Yap, Nam Sang Cheung, Sharon La FontaineAuthor(s): Michael A. Cater, Stephanie Materia, Zhiguang Xiao, Kamil Wolyniec, Susan M. Ackland, Yann W. Yap, Nam Sang Cheung, Sharon La Fontaine -
PcoE — A metal sponge expressed to the periplasm of copper resistance Escherichia coli. Implication of its function role in copper resistanceJournal of Inorganic Biochemistry
- Page(s): 186--197
- Year: 10/2012
Author(s): Matthias Zimmermann, Saumya R. Udagedara, Chak Ming Sze, Timothy M. Ryan, Geoffrey J. Howlett, Zhiguang Xiao, Anthony G. WeddAuthor(s): Matthias Zimmermann, Saumya R. Udagedara, Chak Ming Sze, Timothy M. Ryan, Geoffrey J. Howlett, Zhiguang Xiao, Anthony G. Wedd -
Interaction of cisplatin and analogue Pt(en)Cl2 with the copper metallo-chaperone Atox1Metallomics
- Year: 2013
Author(s): Chak Ming Sze, Zhenyu Shi, George N. Khairallah, Linda Feketeová, Richard A. J. O'Hair, Zhiguang Xiao, Paul S. Donnelly, Anthony G. WeddAuthor(s): Chak Ming Sze, Zhenyu Shi, George N. Khairallah, Linda Feketeová, Richard A. J. O'Hair, Zhiguang Xiao, Paul S. Donnelly, Anthony G. Wedd -
Evaluation of quantitative probes for weaker Cu(i) binding sites completes a set of four capable of detecting Cu(i) affinities from nanomolar to attomolarMetallomics
- Year: 2013
Author(s): Zhiguang Xiao, Lisa Gottschlich, Renate van der Meulen, Saumya R. Udagedara, Anthony G. WeddAuthor(s): Zhiguang Xiao, Lisa Gottschlich, Renate van der Meulen, Saumya R. Udagedara, Anthony G. Wedd -
An integrated study of the affinities of the Aβ16 peptide for Cu( i ) and Cu( ii ): implications for the catalytic production of reactive oxygen speciesMetallomics
- Year: 01/2014
Author(s): Tessa R. Young, Angie Kirchner, Anthony G. Wedd, Zhiguang XiaoAuthor(s): Tessa R. Young, Angie Kirchner, Anthony G. Wedd, Zhiguang Xiao -
Redox sulfur chemistry of the copper chaperone Atox1 is regulated by the enzyme glutaredoxin 1, the reduction potential of the glutathione couple GSSG/2GSH and the availability of Cu( i )Metallomics
- Year: 05/02/2014
Author(s): Jens Brose, Sharon La Fontaine, Anthony G. Wedd, Zhiguang XiaoAuthor(s): Jens Brose, Sharon La Fontaine, Anthony G. Wedd, Zhiguang Xiao -
Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological functionMetallomics
- Year: 2014
Author(s): Su Ling Leong, Tessa R. Young, Kevin J. Barnham, Anthony G. Wedd, Mark G. Hinds, Zhiguang Xiao, Roberto CappaiAuthor(s): Su Ling Leong, Tessa R. Young, Kevin J. Barnham, Anthony G. Wedd, Mark G. Hinds, Zhiguang Xiao, Roberto Cappai -
Metallo-oxidase Enzymes: Design of their Active SitesAustralian Journal of Chemistry
- Page(s): 231
- Year: 2011
Author(s): Zhiguang Xiao, Anthony G. WeddAuthor(s): Zhiguang Xiao, Anthony G. Wedd -
Copper complexes of a novel non-innocent quadridentate ligandChemical Communications
- Year: 2012
Author(s): Gojko Buncic, Zhiguang Xiao, Simon C. Drew, Jonathan M. White, Anthony G. Wedd, Paul S. DonnellyAuthor(s): Gojko Buncic, Zhiguang Xiao, Simon C. Drew, Jonathan M. White, Anthony G. Wedd, Paul S. Donnelly -
Water-soluble Bis(thiosemicarbazonato)copper(II) ComplexesAustralian Journal of Chemistry
- Page(s): 244
- Year: 2011
Author(s): Gojko Buncic, James L. Hickey, Christine Schieber, Jonathan M. White, Peter J. Crouch, Anthony R. White, Zhiguang Xiao, Anthony G. Wedd, Paul S. DonnellyAuthor(s): Gojko Buncic, James L. Hickey, Christine Schieber, Jonathan M. White, Peter J. Crouch, Anthony R. White, Zhiguang Xiao, Anthony G. Wedd, Paul S. Donnelly -
The challenges of using a copper fluorescent sensor (CS1) to track intracellular distributions of copper in neuronal and glial cellsChemical Science
- Year: 2012
Author(s): Katherine A. Price, James L. Hickey, Zhiguang Xiao, Anthony G. Wedd, Simon A. James, Jeffrey R. Liddell, Peter J. Crouch, Anthony R. White, Paul S. DonnellyAuthor(s): Katherine A. Price, James L. Hickey, Zhiguang Xiao, Anthony G. Wedd, Simon A. James, Jeffrey R. Liddell, Peter J. Crouch, Anthony R. White, Paul S. Donnelly -
Molecular Basis of the Cooperative Binding of Cu(I) and Cu(II) to the CopK Protein fromCupriavidus metalliduransCH34Biochemistry
- Year: 11/2011
Author(s): Miriam-Rose Ash, Lee Xin Chong, Megan J. Maher, Mark G. Hinds, Zhiguang Xiao, Anthony G. WeddAuthor(s): Miriam-Rose Ash, Lee Xin Chong, Megan J. Maher, Mark G. Hinds, Zhiguang Xiao, Anthony G. Wedd -
Solvation Effects on S K-Edge XAS Spectra of Fe−S Proteins: Normal and Inverse Effects on WT and Mutant RubredoxinJournal of the American Chemical Society
- Year: 09/2010
Author(s): Ning Sun, Abhishek Dey, Zhiguang Xiao, Anthony G. Wedd, Keith O. Hodgson, Britt Hedman, Edward I. SolomonAuthor(s): Ning Sun, Abhishek Dey, Zhiguang Xiao, Anthony G. Wedd, Keith O. Hodgson, Britt Hedman, Edward I. Solomon -
ChemInform Abstract: The Challenges of Determining Metal-Protein AffinitiesChemInform
- Volume: 41
- Page(s): no--no
- Year: 09/07/2010
Author(s): Zhiguang Xiao, Anthony G. WeddAuthor(s): Zhiguang Xiao, Anthony G. Wedd -
Unification of the copper(I) binding affinities of the metallo-chaperones Atx1, Atox1, and related proteins: Detection probes and affinity standardsJournal of Biological Chemistry
- Volume: 286
- Page(s): 11047-11055
- Year: 2011
Author(s): Xiao, Z., Brose, J., Schimo, S., Ackland, S.M., La Fontaine, S., Wedd, A.G.Author(s): Xiao, Z., Brose, J., Schimo, S., Ackland, S.M., La Fontaine, S., Wedd, A.G. -
Water-soluble bis(thiosemicarbazonato)copper(II) complexesAustralian Journal of Chemistry
- Volume: 64
- Page(s): 244-252
- Year: 2011
Author(s): Buncic, G., Hickey, J.L., Schieber, C., White, J.M., Crouch, P.J., White, A.R., Xiao, Z., Wedd, A.G., Donnelly, P.S.Author(s): Buncic, G., Hickey, J.L., Schieber, C., White, J.M., Crouch, P.J., White, A.R., Xiao, Z., Wedd, A.G., Donnelly, P.S. -
Metallo-oxidase enzymes: Design of their active sitesAustralian Journal of Chemistry
- Volume: 64
- Page(s): 231-238
- Year: 2011
Author(s): Xiao, Z., Wedd, A.G.Author(s): Xiao, Z., Wedd, A.G. -
The challenges of determining metal–protein affinitiesNatural Product Reports
- Year: 2010
Author(s): Zhiguang Xiao, Anthony G. WeddAuthor(s): Zhiguang Xiao, Anthony G. Wedd -
Metal specificities of Arabidopsis zinc and copper transport proteins match the relative, but not the absolute, affinities of their N-terminal domainsChemical Communications
- Year: 2009
Author(s): Matthias Zimmermann, Zhiguang Xiao, Christopher S. Cobbett, Anthony G. WeddAuthor(s): Matthias Zimmermann, Zhiguang Xiao, Christopher S. Cobbett, Anthony G. Wedd -
Copper Resistance inE. coli: The Multicopper Oxidase PcoA Catalyzes Oxidation of Copper(I) in CuICuII‐PcoCChemBioChem
- Volume: 9
- Page(s): 1579--1582
- Year: 02/07/2008
Author(s): Karrera Y. Djoko, Zhiguang Xiao, Anthony G. WeddAuthor(s): Karrera Y. Djoko, Zhiguang Xiao, Anthony G. Wedd -
Electron paramagnetic resonance characterization of the copper-resistance protein PcoC from Escherichia coliJBIC Journal of Biological Inorganic Chemistry
- Volume: 13
- Page(s): 899--907
- Year: 04/2008
Author(s): Simon C. Drew, Karrera Y. Djoko, Lianyi Zhang, Melissa Koay, John F. Boas, John R. Pilbrow, Zhiguang Xiao, Kevin J. Barnham, Anthony G. WeddAuthor(s): Simon C. Drew, Karrera Y. Djoko, Lianyi Zhang, Melissa Koay, John F. Boas, John R. Pilbrow, Zhiguang Xiao, Kevin J. Barnham, Anthony G. Wedd -
A Water-Soluble Bis(thiosemicarbazone) Ligand. A Sensitive Probe and Metal Buffer for ZincInorganic Chemistry
- Year: 05/04/2010
Author(s): Gojko Buncic, Paul S. Donnelly, Brett M. Paterson, Jonathan M. White, Matthias Zimmermann, Zhiguang Xiao, Anthony G. WeddAuthor(s): Gojko Buncic, Paul S. Donnelly, Brett M. Paterson, Jonathan M. White, Matthias Zimmermann, Zhiguang Xiao, Anthony G. Wedd -
Transfer of Copper between Bis(thiosemicarbazone) Ligands and Intracellular Copper-Binding Proteins. Insights into Mechanisms of Copper Uptake and Hypoxia SelectivityInorganic Chemistry
- Year: 05/2008
Author(s): Zhiguang Xiao, Paul S. Donnelly, Matthias Zimmermann, Anthony G. WeddAuthor(s): Zhiguang Xiao, Paul S. Donnelly, Matthias Zimmermann, Anthony G. Wedd -
Metal Binding Affinities ofArabidopsisZinc and Copper Transporters: Selectivities Match the Relative, but Not the Absolute, Affinities of their Amino-Terminal Domains,Biochemistry
- Year: 2009
Author(s): Matthias Zimmermann, Oliver Clarke, Jacqui M. Gulbis, David W. Keizer, Renee S. Jarvis, Christopher S. Cobbett, Mark G. Hinds, Zhiguang Xiao, Anthony G. WeddAuthor(s): Matthias Zimmermann, Oliver Clarke, Jacqui M. Gulbis, David W. Keizer, Renee S. Jarvis, Christopher S. Cobbett, Mark G. Hinds, Zhiguang Xiao, Anthony G. Wedd -
Unprecedented Binding Cooperativity between CuIand CuIIin the Copper Resistance Protein CopK fromCupriavidus metalliduransCH34: Implications from Structural Studies by NMR Spectroscopy and X-Ray CrystallographyJournal of the American Chemical Society
- Year: 03/2009
Author(s): Lee Xin Chong, Miriam-Rose Ash, Megan J. Maher, Mark G. Hinds, Zhiguang Xiao, Anthony G. WeddAuthor(s): Lee Xin Chong, Miriam-Rose Ash, Megan J. Maher, Mark G. Hinds, Zhiguang Xiao, Anthony G. Wedd -
Reaction Mechanisms of the Multicopper Oxidase CueO fromEscherichia coliSupport Its Functional Role as a Cuprous OxidaseJournal of the American Chemical Society
- Year: 02/2010
Author(s): Karrera Y. Djoko, Lee Xin Chong, Anthony G. Wedd, Zhiguang XiaoAuthor(s): Karrera Y. Djoko, Lee Xin Chong, Anthony G. Wedd, Zhiguang Xiao -
Interaction of cisplatin and analogues with a Met-rich protein siteJournal of Biological Inorganic Chemistry
- Volume: 14
- Page(s): 163-165
- Year: 2009
Author(s): Sze, C.M., Khairallah, G.N., Xiao, Z., Donnelly, P.S., O'Hair, R.A.J., Wedd, A.G.Author(s): Sze, C.M., Khairallah, G.N., Xiao, Z., Donnelly, P.S., O'Hair, R.A.J., Wedd, A.G. -
Copper and Alzheimer's diseaseCurrent Opinion in Chemical Biology
- Page(s): 128--133
- Year: 04/2007
Author(s): Paul S Donnelly, Zhiguang Xiao, Anthony G WeddAuthor(s): Paul S Donnelly, Zhiguang Xiao, Anthony G Wedd -
Metal binding in CopC from P. syringae pathovar tomatoJournal of Inorganic Biochemistry
- Page(s): 168
- Year: 07/2003
Author(s): Melissa Koay, Zhiguang Xiao, Anthony G. WeddAuthor(s): Melissa Koay, Zhiguang Xiao, Anthony G. Wedd -
Application of NMRD to Hydration of Rubredoxin and a Variant Containing a (Cys-S)3FeIII(OH) SiteBiophysical Journal
- Page(s): 545--551
- Year: 01/2003
Author(s): Ivano Bertini, Claudio Luchinat, Kirill Nerinovski, Giacomo Parigi, Maddalena Cross, Zhiguang Xiao, Anthony G. WeddAuthor(s): Ivano Bertini, Claudio Luchinat, Kirill Nerinovski, Giacomo Parigi, Maddalena Cross, Zhiguang Xiao, Anthony G. Wedd -
The C-terminal domain of the membrane copper pump Ctrl in yeast binds Cu as a cuprous-thiolate polynuclear clusterJournal of Inorganic Biochemistry
- Page(s): 251
- Year: 07/2003
Author(s): Zhiguang Xiao, Graham N. George, Anthony G. WeddAuthor(s): Zhiguang Xiao, Graham N. George, Anthony G. Wedd -
Conserved Mechanism of Copper Binding and Transfer. A Comparison of the Copper-Resistance Proteins PcoC from Escherichia coli and CopC from Pseudomonas syringaeInorganic Chemistry
- Year: 05/2007
Author(s): Karrera Y. Djoko, Zhiguang Xiao, David L. Huffman, Anthony G. WeddAuthor(s): Karrera Y. Djoko, Zhiguang Xiao, David L. Huffman, Anthony G. Wedd -
Intermolecular Transfer of Copper Ions from the CopC Protein ofPseudomonas syringae. Crystal Structures of Fully Loaded CuICuIIFormsJournal of the American Chemical Society
- Year: 05/2006
Author(s): Lianyi Zhang, Melissa Koay, Megan J. Maher, Zhiguang Xiao, Anthony G. WeddAuthor(s): Lianyi Zhang, Melissa Koay, Megan J. Maher, Zhiguang Xiao, Anthony G. Wedd -
C-Terminal Domain of the Membrane Copper Transporter Ctr1 fromSaccharomyces cerevisiaeBinds Four Cu(I) Ions as a Cuprous-Thiolate Polynuclear Cluster: Sub-femtomolar Cu(I) Affinity of Three Proteins Involved in Copper TraffickingJournal of the American Chemical Society
- Year: 03/2004
Author(s): Zhiguang Xiao, Fionna Loughlin, Graham N. George, Geoffrey J. Howlett, Anthony G. WeddAuthor(s): Zhiguang Xiao, Fionna Loughlin, Graham N. George, Geoffrey J. Howlett, Anthony G. Wedd -
CopC Protein fromPseudomonassyringae: Intermolecular Transfer of Copper from Both the Copper(I) and Copper(II) SitesInorganic Chemistry
- Year: 07/2005
Author(s): Melissa Koay, Lianyi Zhang, Binsheng Yang, Megan J. Maher, Zhiguang Xiao, Anthony G. WeddAuthor(s): Melissa Koay, Lianyi Zhang, Binsheng Yang, Megan J. Maher, Zhiguang Xiao, Anthony G. Wedd -
Protonless 13C direct detection NMR: Characterization of the 37 kDa trimeric protein CutA1Proteins: Structure, Function and Genetics
- Volume: 70
- Page(s): 1196-1205
- Year: 2008
Author(s): Bertini, I., Jiménez, B., Pierattelli, R., Wedd, A.G., Xiao, Z.Author(s): Bertini, I., Jiménez, B., Pierattelli, R., Wedd, A.G., Xiao, Z. -
Application of NMRD to hydration of rubredoxin and a variant containing a (Cys-S)
3 FeIII(OH) siteBiophysical Journal- Volume: 84
- Page(s): 545-551
- Year: 2003
Author(s): Bertini, I., Luchinat, C., Nerinovski, K., Parigi, G., Cross, M., Xiao, Z., Wedd, A.G.Author(s): Bertini, I., Luchinat, C., Nerinovski, K., Parigi, G., Cross, M., Xiao, Z., Wedd, A.G. -
Mutation of the surface valine residues 8 and 44 in the rubredoxin from Clostridium pasteurianum: solvent access versus structural changes as determinants of reversible potentialJBIC Journal of Biological Inorganic Chemistry
- Volume: 5
- Page(s): 75--84
- Year: 2000
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Rubredoxin from Clostridium pasteurianum. Structures of G10A, G43A and G10VG43A mutant proteins. Mutation of conserved glycine 10 to valine causes the 9--10 peptide link to invertActa Crystallographica Section D: Biological Crystallography
- Volume: 55
- Page(s): 962--968
- Year: 1999
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Molecular engineering at the active site of rubredoxinJOURNAL OF INORGANIC BIOCHEMISTRY
- Volume: 74
- Page(s): 335--335
- Year: 1999
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RESONANCE RAMAN EVIDENCE FOR (S-Cys)̃ 3Fe^ I^ I^ I (OH) CENTERS IN RUBREDOXIN CYSTEINE TO GLYCINE OR ALANINE MUTANTSINTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY
- Year: 2002
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A C-terminal domain of the membrane copper pump Ctr1 exchanges copper(i) with the copper chaperone Atx1Chemical Communications
- Year: 02/2002
Author(s): Zhiguang Xiao, Anthony G. WeddAuthor(s): Zhiguang Xiao, Anthony G. Wedd -
Removal of a cysteine ligand from rubredoxin: assembly of Fe2S2 and Fe(S-Cys)3(OH) centresJournal of Biological Inorganic Chemistry
- Volume: 7
- Page(s): 781--790
- Year: 01/09/2002
Author(s): Maddalena Cross, Zhiguang Xiao, Estelle M. Maes, Roman S. Czernuszewicz, Simon C. Drew, John R. Pilbrow, Graham N. George, Anthony G. WeddAuthor(s): Maddalena Cross, Zhiguang Xiao, Estelle M. Maes, Roman S. Czernuszewicz, Simon C. Drew, John R. Pilbrow, Graham N. George, Anthony G. Wedd -
Redox thermodynamics of mutant forms of the rubredoxin from Clostridiumpasteurianum: identification of a stable FeIII(S-Cys)3(OH) centre in the C6S mutantJBIC Journal of Biological Inorganic Chemistry
- Volume: 6
- Page(s): 638--649
- Year: 05/2001
Author(s): Zhiguang Xiao, Andrew R. Gardner, Maddalena Cross, Estelle M. Maes, Roman S. Czernuszewicz, Marco Sola, Anthony G. WeddAuthor(s): Zhiguang Xiao, Andrew R. Gardner, Maddalena Cross, Estelle M. Maes, Roman S. Czernuszewicz, Marco Sola, Anthony G. Wedd -
The dependence of reversible potentials on the form of modification of edge plane pyrolytic graphite electrodes in voltammetric studies on rubredoxin and ferredoxin from Clostridium pasteurianumElectrochemistry Communications
- Page(s): 309--314
- Year: 08/1999
Author(s): Zhiguang Xiao, Megan J Lavery, Alan M Bond, Anthony G WeddAuthor(s): Zhiguang Xiao, Megan J Lavery, Alan M Bond, Anthony G Wedd -
Mutation of the surface valine residues 8 and 44 in the rubredoxin from Clostridium pasteurianum: Solvent access versus structural changes as determinants of reversible potentialJournal of Biological Inorganic Chemistry
- Volume: 5
- Page(s): 75-84
- Year: 2000
Author(s): Xiao, Z., Maher, M.J., Cross, M., Bond, C.S., Guss, J.M., Wedd, A.G.Author(s): Xiao, Z., Maher, M.J., Cross, M., Bond, C.S., Guss, J.M., Wedd, A.G. -
Erratum: Redox thermodynamics of mutant forms of the rubredoxin from Clostridium pasteurianum: Identification of a stable FeIII(S-Cys)3(OH) centre in the C6S mutant (Journal of Biological Inorganic Chemistry (2001) 6 (638-649))Journal of Biological Inorganic Chemistry
- Volume: 6
- Page(s): 753
- Year: 2001
Author(s): Xiao, Z., Gardner, A.R., Cross, M., Maes, E.M., Czeruszewicz, R.S., Sola, M., Wedd, A.G.Author(s): Xiao, Z., Gardner, A.R., Cross, M., Maes, E.M., Czeruszewicz, R.S., Sola, M., Wedd, A.G. -
The rubredoxin from Clostridium pasteurianum: mutation of the iron cysteinyl ligands to serine. Crystal and molecular structures of oxidized and dithionite-treated forms of the Cys42Ser mutantJournal of the American Chemical Society
- Volume: 120
- Page(s): 4135--4150
- Year: 1998
-
Multifield magnetization saturation measurements on rubredoxin samples from Clostridium pasteurianumJournal of Inorganic Biochemistry
- Volume: 1
- Page(s): 261
- Year: 1997
-
Complexes Containing cis- [Mo V O 2 ] + and cis -[Mo V O(OH)] 2+ CentersJournal of the American Chemical Society
- Year: 01/1996
Author(s): Zhiguang Xiao, Robert W. Gable, Anthony G. Wedd, Charles G. YoungAuthor(s): Zhiguang Xiao, Robert W. Gable, Anthony G. Wedd, Charles G. Young -
A Catalytic Cycle Related to Molybdenum Enzymes Containing [Mo VI O 2 ] 2+ Oxidized Active SitesInorganic Chemistry
- Year: 01/1996
Author(s): Zhiguang Xiao, Michael A. Bruck, John H. Enemark, Charles G. Young, Anthony G. WeddAuthor(s): Zhiguang Xiao, Michael A. Bruck, John H. Enemark, Charles G. Young, Anthony G. Wedd -
The Rubredoxin from Clostridium pasteurianum : Mutation of the Conserved Glycine Residues 10 and 43 to Alanine and ValineInorganic Chemistry
- Year: 01/1996
Author(s): Mustafa Ayhan, Zhiguang Xiao, Megan J. Lavery, Amanda M. Hamer, Kerry W. Nugent, Sergio D. B. Scrofani, Mitchell Guss, Anthony G. WeddAuthor(s): Mustafa Ayhan, Zhiguang Xiao, Megan J. Lavery, Amanda M. Hamer, Kerry W. Nugent, Sergio D. B. Scrofani, Mitchell Guss, Anthony G. Wedd -
Dioxomolybdenum(VI) Complexes of Tripodal Nitrogen-Donor Ligands: Syntheses and Spectroscopic, Structural, and Electrochemical Studies, Including the Generation of EPR-Active Molybdenum(V) Species in SolutionInorganic Chemistry
- Year: 01/1996
Author(s): Zhiguang Xiao, Michael A. Bruck, Colleen Doyle, John H. Enemark, Carina Grittini, Robert W. Gable, Anthony G. Wedd, Charles G. YoungAuthor(s): Zhiguang Xiao, Michael A. Bruck, Colleen Doyle, John H. Enemark, Carina Grittini, Robert W. Gable, Anthony G. Wedd, Charles G. Young -
Rubredoxin from Clostridium pasteurianum : Mutation of the Conserved Cysteine and Glycine ResiduesTransition Metal Sulfur Chemistry
- Year: 11/1996
Author(s): Mustafa Ayhan, Zhiguang Xiao, Megan J. Lavery, Amanda M. Hammer, Sergio D. B. Scrofani, Anthony G. WeddAuthor(s): Mustafa Ayhan, Zhiguang Xiao, Megan J. Lavery, Amanda M. Hammer, Sergio D. B. Scrofani, Anthony G. Wedd -
The dependence of reversible potentials on the form of modification of edge plane pyrolytic graphite electrodes in voltammetric studies on rubredoxin and ferredoxin from Clostridium pasteurianumElectrochemistry Communications
- Volume: 1
- Page(s): 309-314
- Year: 1999
Author(s): Xiao, Z., Lavery, M.J., Bond, A.M., Wedd, A.G.Author(s): Xiao, Z., Lavery, M.J., Bond, A.M., Wedd, A.G. -
Rubredoxin from Clostridium pasteurianum. Structures of G10A, G43A and G10VG43A mutant proteins. Mutation of conserved glycine 10 to valine causes the 9-10 peptide link to invertActa Crystallographica Section D: Biological Crystallography
- Volume: 55
- Page(s): 962-968
- Year: 1999
Author(s): Maher, M.J., Xiao, Z., Wilce, M.C.J., Guss, J.M., Wedd, A.G.Author(s): Maher, M.J., Xiao, Z., Wilce, M.C.J., Guss, J.M., Wedd, A.G. -
The rubredoxin from Clostridium pasteurianum: Mutation of the iron cysteinyl ligands to serine. Crystal and molecular structures of oxidized and dithionite-treated forms of the Cys42Ser mutantJournal of the American Chemical Society
- Volume: 120
- Page(s): 4135-4150
- Year: 1998
Author(s): Xiao, Z., Lavery, M.J., Ayhan, M., Scrofani, S.D.B., Wilce, M.C.J., Guss, J.M., Tregloan, P.A., George, G.N., Wedd, A.G.Author(s): Xiao, Z., Lavery, M.J., Ayhan, M., Scrofani, S.D.B., Wilce, M.C.J., Guss, J.M., Tregloan, P.A., George, G.N., Wedd, A.G. -
The cis-dioxomolybdenum(V) radical anion, [{HB(Me2C2N3)3}MoO2(SPh)]?Journal of the Chemical Society, Chemical Communications
- Year: 1994
Author(s): Zhiguang Xiao, Robert W. Gable, Anthony G. Wedd, Charles G. YoungAuthor(s): Zhiguang Xiao, Robert W. Gable, Anthony G. Wedd, Charles G. Young -
Dioxomolybdenum(VI) Complexes of Tripodal Nitrogen-Donor Ligands: Syntheses and Spectroscopic, Structural, and Electrochemical Studies, Including the Generation of EPR-Active Molybdenum(V) Species in SolutionInorganic Chemistry
- Year: 11/1995
Author(s): Zhiguang Xiao, Michael A. Bruck, Colleen Doyle, John H. Enemark, Carina Grittini, Robert W. Gable, Anthony G. Wedd, Charles G. YoungAuthor(s): Zhiguang Xiao, Michael A. Bruck, Colleen Doyle, John H. Enemark, Carina Grittini, Robert W. Gable, Anthony G. Wedd, Charles G. Young -
A single model displaying all the important centers and processes involved in catalysis by molybdoenzymes containing [MoVIO2]2+ active sitesJournal of the American Chemical Society
- Year: 11/1992
Author(s): Zhiguang Xiao, Charles G. Young, John H. Enemark, Anthony G. WeddAuthor(s): Zhiguang Xiao, Charles G. Young, John H. Enemark, Anthony G. Wedd -
Isovalent and Mixed-Valent Dinuclear .mu.-Oxo and .mu.-Oxo .mu.-Disulfido Complexes of Molybdenum(V) and Molybdenum(VI)Inorganic Chemistry
- Year: 08/1994
Author(s): Zhiguang Xiao, John H. Enemark, Anthony G. Wedd, Charles G. YoungAuthor(s): Zhiguang Xiao, John H. Enemark, Anthony G. Wedd, Charles G. Young -
Rubredoxin from Clostridium pasteurianum: Mutation of the Conserved Cysteine and Glycine ResiduesACS Symposium Series
- Volume: 653
- Page(s): 39-56
- Year: 1996
Author(s): Ayhan, M., Xiao, Z., Lavery, M.J., Hammer, A.M., Scrofani, S.D.B., Wedd, A.G.Author(s): Ayhan, M., Xiao, Z., Lavery, M.J., Hammer, A.M., Scrofani, S.D.B., Wedd, A.G. -
The Rubredoxin from Clostridium pasteurianum: Mutation of the Conserved Glycine Residues 10 and 43 to Alanine and ValineInorganic Chemistry
- Volume: 35
- Page(s): 5902-5911
- Year: 1996
Author(s): Ayhan, M., Xiao, Z., Lavery, M.J., Hamer, A.M., Nugent, K.W., Scrofani, S.D.B., Guss, M., Wedd, A.G.Author(s): Ayhan, M., Xiao, Z., Lavery, M.J., Hamer, A.M., Nugent, K.W., Scrofani, S.D.B., Guss, M., Wedd, A.G. -
A Catalytic Cycle Related to Molybdenum Enzymes Containing [MoVIO
2 ]2+ Oxidized Active SitesInorganic Chemistry- Volume: 35
- Page(s): 7508-7515
- Year: 1996
Author(s): Xiao, Z., Bruck, M.A., Enemark, J.H., Young, C.G., Wedd, A.G.Author(s): Xiao, Z., Bruck, M.A., Enemark, J.H., Young, C.G., Wedd, A.G. -
Complexes containing cis-[MoVO
2 ]+ and cis-[MoVO(OH)]2+ centersJournal of the American Chemical Society- Volume: 118
- Page(s): 2912-2921
- Year: 1996
Author(s): Xiao, Z., Gable, R.W., Wedd, A.G., Young, C.G.Author(s): Xiao, Z., Gable, R.W., Wedd, A.G., Young, C.G. -
Trimethylsilyloxo complexes of oxomolybdenum(V). Coupled electron-electrophile transfer reactionsJournal of Biological Inorganic Chemistry
- Volume: 1
- Page(s): 415-423
- Year: 1996
Author(s): Xiao, Z., Bruck, M.A., Enemark, J.H., Young, C.G., Wedd, A.G.Author(s): Xiao, Z., Bruck, M.A., Enemark, J.H., Young, C.G., Wedd, A.G. -
The cis-dioxomolybdenum(V) radical anion, [{HB(Me
2 C2 N3 )3 }MoO2 (SPh)]-Journal of the Chemical Society, Chemical Communications- Page(s): 1295-1296
- Year: 1994
Author(s): Xiao, Z., Gable, R.W., Wedd, A.G., Young, C.G.Author(s): Xiao, Z., Gable, R.W., Wedd, A.G., Young, C.G. -
Preparation and characterization of molybdophosphate complexes of rare earth elementsFujian Shifan Daxue Xuebao, Ziran Kexueban (J. Fujian Normal University, Nat. Sci.)
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POTENTIOMETRIC TITRATION OF CERIUM IN RARE EARTH MIXTURESChin. J. Anal. Chem.
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Determinants of the reduction potential in rubredoxins, the simplest iron-sulfur electrontransfer proteinsModern Coordination ChemistryAuthor(s): Zhiguang Xiao, Anthony G. WeddAuthor(s): Zhiguang Xiao, Anthony G. Wedd
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