Dr Rachel McQuade is a postdoctoral research fellow in the Digestive Physiology and Nutrition Laboratory at the Florey Institute of Neuroscience and Mental Health.
Dr McQuade completed her PhD in 2017 studying chemotherapy-induced enteric neurotoxicity and neuroprotection. Her work was amongst the first in the world to investigate the relationship between chemotherapy-induced enteric neuropathy and gut dysfunction, highlighting for the first time the enteric nervous system as a therapeutic target to alleviate the debilitating side-effects of chemotherapy.
Dr McQuade undertook her first postdoctoral position at Monash Institute of Pharmaceutical Sciences (MIPS) where she worked as a lead investigator in an academic-industry alliance investigating the mechanisms of novel compounds and validating drug targets in various models of GI disease and inflammation.
Since moving to the Florey in 2018, Dr McQuade’s research has aimed to explore the relationship between gut and brain impairment in Parkinson’s disease. Her work utilises mouse models of Parkinson's disease to systematically investigate structural and functional deterioration throughout the nervous system and seeks to understand the temporal and causal relations between development of enteric nervous system injury, central nervous system injury, motor symptoms and gut dysfunction. Dr McQuade’s goal is to determine to role of the gut in PD pathogenesis and progression and develop improved therapies/interventions that can be rapidly translated to improve clinical outcomes for Parkinson’s disease patients.
• Dr Laura Edgington-Mitchell, Bio21
• A/Prof David Finkelstein, Florey Institute of Neuroscience and Mental Health
• A/Prof Kulmira Nurgali, Western centre for Health Research and Education
• Dr Holly Chinnery, University of Melbourne
Awards and achievements
Grants and Fellowships:
• Jack Brockhoff Early Career Research Grant, CIA; $99,869 (2019-2021)
• Early-Mid Career Collaborative Grant, CIA; $12,500, (2018-2019)
• John Collier Postdoctoral Travel Scholarship, CIA; $5,000 (2019)
• Victoria University Publication Grant, CIA; $4,200 (2017)
• Department of Anatomy & Neuroscience Travel Award, University of Melbourne (2019)
• Poster of Excellence, New Zealand Society of Gastroenterology (2017)
• Postgraduate Travel Award, College of Health & Biomedicine (2016)
• Victoria University Outstanding PhD Researcher (2014)
Showing 10 of 15. VIEW ALL
Colorectal cancer chemotherapy: The evolution of treatment and new approachesCurrent Medicinal Chemistry
Impact of chemotherapy on gastrointestinal functions and the enteric nervous systemMaturitas
Neurotoxicity associated with platinum-based anti-cancer agents: What are the implications of copper transporters?Current Medicinal Chemistry
irinotecan-induced gastrointestinal dysfunction is associated with enteric neuropathy, but increased numbers of cholinergic myenteric neuronsFrontiers in Physiology
Inflammation-associated changes in DOR expression and function in the mouse colonAmerican journal of physiology. Gastrointestinal and liver physiology
The potentially beneficial central nervous system activity profile of ivacaftor and its metabolitesERS Monograph
Oxaliplatin-induced enteric neuronal loss and intestinal dysfunction is prevented by co-treatment with BGP-15British Journal of Pharmacology
Effects of Oxaliplatin Treatment on the Myenteric Plexus Innervation and Glia in the Murine Distal ColonJournal of Histochemistry and Cytochemistry
Oxaliplatin-induced changes in microbiota, TLR4+ cells and enhanced HMGB1 expression in the murine colonPLoS ONE
PARP inhibition in platinum-based chemotherapy: Chemopotentiation and neuroprotectionPharmacological Research
Chemotherapy-induced constipation and diarrhea: Pathophysiology, current and emerging treatmentsFrontiers in Pharmacology
Gastrointestinal dysfunction and enteric neurotoxicity following treatment with anticancer chemotherapeutic agent 5-fluorouracilNeurogastroenterology and Motility
Effects of Oxaliplatin Treatment on the Enteric Glial Cells and Neurons in the Mouse IleumJournal of Histochemistry and Cytochemistry
Role of oxidative stress in oxaliplatin-induced enteric neuropathy and colonic dysmotility in miceBritish Journal of Pharmacology
Anti-colorectal cancer chemotherapy-induced diarrhoea: current treatments and side-effectsInternational Journal of Clinical Medicine
Showing 10 of 15. VIEW ALL
Brain health affects all Australians. You can support our research by making a donation or a bequest.