Understanding sex differences in the role of cocaine and amphetamine regulated transcript (CART) in binge alcohol consumption
We have recently identified that the neuropeptide CART regulates binge drinking in a sex-specific manner. While these effects are specific to alcohol, region-specific actions and sex-dependent mechanisms regulating binge alcohol consumption remain elusive.
This project aims to understand the brain regions and neurocircuitry where CART mediates binge drinking in both male and female mice. We will use cutting edge technology including RNAscope, calcium imaging and designer receptors activated exclusively by designer drugs (DREADDs) to dissect the endogenous and functional role of CART in binge drinking.
Latest Florey news for Addiction
Key brain region identified for alcohol relapse
Florey scientists have identified a key brain region involved in relapse to alcohol-drinking in an animal model
Florey Researcher to play key role in the World Health Organisation’s International Society for Biomedical Research on Alcoholism
Professor Andrew Lawrence will play an important role in increasing global knowledge of alcohol use disorder through a new appointment to the International Society for Biomedical Research on Alcoholism (ISBRA).
Current and emerging treatments for drug addiction
Alcohol is the most widely used drug in Australia. The age group with the greatest number of Australians who drink daily is 70+ years and around 1 in 5 (17.1%) Australians over the age of 14 drink at levels that put them at risk of alcohol-related harm.
Brain health affects all Australians. You can support our research by making a donation or a bequest.