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Understanding sex differences in the role of cocaine and amphetamine regulated transcript (CART) in binge alcohol consumption

We have recently identified that the neuropeptide CART regulates binge drinking in a sex-specific manner. While these effects are specific to alcohol, region-specific actions and sex-dependent mechanisms regulating binge alcohol consumption remain elusive.  

This project aims to understand the brain regions and neurocircuitry where CART mediates binge drinking in both male and female mice. We will use cutting edge technology including RNAscope, calcium imaging and designer receptors activated exclusively by designer drugs (DREADDs) to dissect the endogenous and functional role of CART in binge drinking.

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