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Search the P2X7 related biomarkers for Alzheimer’s disease

Alzheimer’s disease is an age-related dementia with major impact in people aged 60 or over.

Typical symptoms including memory loss and cognitive impairment but the pathogenesis is unclear and treatment options are limited. Recent evidence suggests the P2X7 receptor may be involved in the pathogenesis of this disease. This project will study the peripheral blood cells obtained from Alzheimer’s disease patients, subjects with minor cognitive impairment and age matched healthy controls. The P2X7 expression and function on mononuclear cells and various phenotyping and serological assays will be performed. The diagnostic and prognostic values of P2X7 expression and function will be evaluated. This work may provide a useful biomarker for the diagnosis and prognosis of Alzheimer’s disease, as well as the possible pathogenesis mechanism.

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