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Predicting the recovery of walking after stroke

Who will recover the ability to walk after stroke is poorly understood, but is an important question for stroke survivors and clinicians. 

Aims

To develop evidence based models to predict the recovery of walking after stroke.

The statistical modelling of large data sets allows us to better understand which aspects of patients’ stroke and medical condition will predict their recovery. Recent data modelling studies have identified specific patient characteristics from within 72 hours of stroke onset that will predict the amount of arm use that stroke survivors will have at 6 months after stroke 1-3.

This study will involve the analysis of a large data set (n = 2104) from the recently completed international stroke study “A Very Early Rehabilitation Trial (AVERT)”4 that investigated the effect of very early and intense rehabilitation after stroke. With the support of expert statisticians and clinical researchers, data will be analysed to determine which patient related characteristics early after stroke will predict the ability to walk at 3 and 12 months after stroke.

Students will work within the Centre for Research Excellence in Stroke, based at the Florey Institute in Heidelberg.

Key references:

Winters C, van Wegen EEH, Daffertshofer A, Kwakkel G. Generalizability of the Proportional Recovery Model for the Upper Extremity After an Ischemic Stroke. Neurorehab Neural Re. 2015; 29(7): 614-22.

Byblow WD, Stinear CM, Barber PA, Petoe MA, Ackerley SJ. Proportional Recovery After Stroke Depends on Corticomotor Integrity. Ann Neurol. 2015; 78(6): 848-59.

Prabhakaran S, Zarahn E, Riley C, Speizer A, Chong JY, Lazar RM, et al. Inter-individual variability in the capacity for motor recovery after ischemic stroke. Neurorehab Neural Re. 2008; 22(1): 64-71.

The AVERT Trial Collaboration group, Bernhardt J, Langhorne P, Lindley RI, Thrift AG, Ellery F, et al. Efficacy and safety of very early mobilisation within 24 h of stroke onset (AVERT): a randomised controlled trial. Lancet. 2015; 386(9988): 46-55.

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