BANNER BABYhttps://www.florey.edu.au/uploads/banner-subpages/Tractography_cropped.jpg

Perfusion MRI: novel methods to image cerebral blood flow and brain function

Magnetic Resonance Imaging (MRI) provides a powerful non-invasive tool to measure the rate of blood delivery to brain tissue (also known as cerebral perfusion).

Cerebral perfusion plays an essential role in tissue viability and function, and it is implicated in many diseases (such as stroke, epilepsy, and tumours). Our group is among the international leaders in the development of Perfusion MRI methods. This PhD project will involve the development of novel methods to measure and analyse Perfusion MRI data, in particular using the technique known as Arterial Spin Labelling (ASL). These methods will then be used to investigate brain disorders (e.g. stroke, epilepsy, dementia, etc.), and/or to characterise whole-brain networks (e.g. with connectomics) in the healthy brain and how these networks are disrupted by disease. ASL Perfusion MRI offers a number of important advantages compared with more traditional BOLD fMRI methods to study brain networks, including quantitation, reduced image distortions and signal drop-out, increased spatial specificity, and increased sensitivity to low task frequency paradigms.

Calamante F, Thomas DL, Pell GS, Wiersma J, Turner R. Measuring cerebral blood flow using Magnetic Resonance Imaging techniques. J. Cereb. Blood Flow Metab. 19:701-735 (1999).

Liang X, Connelly A, Calamante F. Graph analysis of resting-state ASL perfusion MRI data: nonlinear correlations among CBF and network metrics. NeuroImage 87: 265–275 (2014).

Liang X, Connelly A, Calamante F. Improved partial volume correction for single inversion time arterial spin labeling data. Magn. Reson. Med. 69: 531–537 (2013).

Liang X, Tournier J-D, Masterton R, Connelly A, Calamante F. A k-space sharing 3D GRASE pseudocontinuous ASL method for whole-brain resting-state functional connectivity. Int. J. Imaging Sys. Techno. 22: 37-43 (2012).

Calamante F, Masterton RAJ, Tournier J-D, Smith RE, Willats L, Raffelt D, Connelly A. Track-weighted functional connectivity (TW-FC): a tool for characterizing the structural-functional connections in the brain. NeuroImage 70: 199–210 (2013).

Wells JA, Thomas DL, King MD, Connelly A, Lythgoe MF, Calamante F. Reduction of Errors in ASL Cerebral Perfusion and Arterial Transit Time Maps using Image De-noising. Magn. Reson. Med. 64:715–724 (2010).

Support us

Brain health affects all Australians.
You can support our research by making a donation or a bequest.

Newsletter

Latest breakthroughs, news, events & more.