Perfusion MRI: novel methods to image cerebral blood flow and brain function

Magnetic Resonance Imaging (MRI) provides a powerful non-invasive tool to measure the rate of blood delivery to brain tissue (also known as cerebral perfusion).

Cerebral perfusion plays an essential role in tissue viability and function, and it is implicated in many diseases (such as stroke, epilepsy, and tumours). Our group is among the international leaders in the development of Perfusion MRI methods. This PhD project will involve the development of novel methods to measure and analyse Perfusion MRI data, in particular using the technique known as Arterial Spin Labelling (ASL). These methods will then be used to investigate brain disorders (e.g. stroke, epilepsy, dementia, etc.), and/or to characterise whole-brain networks (e.g. with connectomics) in the healthy brain and how these networks are disrupted by disease. ASL Perfusion MRI offers a number of important advantages compared with more traditional BOLD fMRI methods to study brain networks, including quantitation, reduced image distortions and signal drop-out, increased spatial specificity, and increased sensitivity to low task frequency paradigms.

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