Parkinson’s disease in a dish
Pluripotent stem cells can be used to generate a wide variety of neuronal subtypes relevant for repair of the central nervous system. Recently we showed that cortical neurons can be transplanted into the part of the cortex damaged by a focal stroke and have a remarkable capacity to integrate into the existing host circuitry in order to restore motor function.
To develop a stem cell model of Parkinson's disease for testing new therapies
This project will extend on these findings in order to explore whether we can restore multiple circuits in more severe models of stoke affecting multiple brain region by transplanting multiple neuronal cell types. The project will utilise a number of in vitro and in vivo techniques including: human pluripotent cell culture; immunochemistry; stereotaxic surgery; analysis of animal behaviour; histology and microscopy.
Latest Florey news for Parkinson’s disease
Current & emerging treatments for Parkinson’s disease: from bedside to bench
In 2014, conservative estimates indicated there were just under 70,000 people living with Parkinson’s in Australia making it the most common major movement disorder and second highest prevalence neurodegenerative condition with only dementia exceeding it.
Parkinson’s research accelerates thanks to Argyrou family grant
Dr Dominic Hare and his world class team from the worlds of chemistry, physics, neuroscience and pathology, have won the 2018 Argyrou Family Fellowship
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