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Nutrition: The control of gut hormone release by nutrients

Gut hormones are essential links in the control of obesity and provide novel opportunities for therapeutic intervention.

Aims

In this project you will work with a team to investigate simultaneously the separate subcellular locations and the mobilisation of vesicles that contain 2 or more hormones in mouse enteroendocrine cells.  Naturally-occurring and synthetic stimulants of nutrient receptors on enteroendocrine cells will be used to promote vesicle translocation and release.

Control of gut hormone release is important to diabetes, weight control and digestive health.  We have made the discovery that hormones that are in the same cells are in separate storage vesicles.  Our observation raises the strong possibility that the release of GI hormones that are colocalised in EEC cells, could be differentially controlled. 

References: 

Furness, JB, Rivera, LR, Cho, H‐J, Bravo, DM, Callaghan, B: The gut as a sensory organ. Nature Rev. Gastroenterol. Hepatol 10, 729-740 (2013).

Cho H-J, Robinson ES, Rivera LR, McMillan PJ, Testro A, Nikfarjam M, Bravo DM & Furness JB. Glucagon-like peptide 1 and peptide YY are in separate storage organelles in enteroendocrine cells. Cell Tissue Res 357, 63-69 (2014).

Fothergill, LJ, Callaghan, B, Hunne, B, Bravo, DM, Furness, JB:  Co-storage of enteroendocrine hormones evaluated at the cell and subcellular levels in male mice.  Endocrinology 158, 2113-2123 (2017) doi: 10.1071/AN17276

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