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Multi-site patch clamp recording of cortical micro networks

In this project the candidate will be trained in the use of an emerging method in brain slice electrophysiology that allows for the simultaneous intracellular recording of 4 connected neurons.

Using this recording mode it is possible to examine how neurons function in coupled micro networks in epileptic and normal brains to lead to a deeper understanding of the functional basis of epilepsy.  If the candidate makes sufficient progress and is motivated this project may also expand into network analysis using multiphoton imaging where 50 or more neurons in a living brain can be labelled with a Ca2+ indicator dye and imaged in real time.

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