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Identification of serum glycoproteins altering innate immunity

Innate immunity is the first line defense of host against invading pathogens. Phagocytosis of non-opsonized particles (bacteria or viruses not coated by immunoglobulin, complement, etc) is an important part of innate immunity.

Our recent findings show that innate phagocytosis is completely abolished by a group of large serum glycoproteins but can be promoted by small peptides within the serum. These proteins/peptides play an important role in regulation of innate immunity and the most potent protein/peptide remains unknown. Identifying these proteins/peptides will lead to a new therapies to boost resistance against infectious diseases.

Techniques involved are chromatography, cell culture, flow cytometry, electrophoresis, western blotting and mass spectrometry.

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