High density multi-electrode array recording of in vitro networks in epilepsy
In this project the candidate will use high density extracellular multielectrode array recordings to investigate large scale network function.
This a level of organization beyond that studied in Project 1 and will reveal fundamental properties of how the hippocampal and thalamocortical networks are altered in genetic models of epilepsy. The goal of these studies is to not only understand more about the neurobiology of epilepsy but also to create novel disease state models for creating anti-epileptic drugs. The method will involve cutting fresh brain slices and using 60 site multi-electrode arrays that enable electrical stimulation and recording from all sites simultaneously. Slices will be subject to various stimulation and pharmacological protocols to reveal aspects about excitability, synaptic transmission and plasticity.
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