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Food entrainment of circadian rhythms

It is clear that a life in which the sleep-activity cycle and meal times are regular is a healthy life. On the other hand, disruption of sleep and irregular meals is unhealthy.

The daily rhythms of sleep, wakefulness, physical activity and eating (circadian rhythms) are coupled to good health. Such rhythms can be set and entrained by light (central clock) or by timed food intake (influencing digestive system rhythms and peripheral clocks). Rhythm disruption by irregular meals, changes in diet, shift work or travel between time zones negatively impacts the functions of various organs and thus our overall health. Despite the importance of circadian rhythms, inadequate knowledge of the baseline circadian rhythmicity in peripheral tissues, the communication pathways for rhythm synchronization, and the potential sex differences holds back understanding of basic mechanisms relevant to health and its disruption.

In this study you will investigate how changed feeding times disrupts circadian rhythms and the expression of nutrient transporters and nutrient handling.

References:

Oparija, L., Rajendran, A., Poncet, N., & Verrey, F. (2019). Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function. The Journal of Physiology597(2), 521-542.

Oparija-Rogenmozere, L., Rajendran, A., Poncet, N., Camargo, S. M., & Verrey, F. (2020). Phosphorylation of mouse intestinal basolateral amino acid uniporter LAT4 is controlled by food-entrained diurnal rhythm and dietary proteins. PloS one15(5), e0233863

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