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The Lewy Body Study

The Lewy Body Study - an observational study that will assess the changes that occur in memory and thinking skills and changes that occur in the body of 100 participants with dementia with Lewy bodies over a 3 year period.

Dementia with Lewy bodies is a common form of dementia in older people, second only to Alzheimer’s disease. It is a condition that shares symptoms of Alzheimer’s disease and Parkinson’s disease and is associated with high rates of morbidity, mortality and poorer quality of life than Alzheimer’s disease. In a longitudinal cohort study of 100 people with dementia with Lewy bodies we aim to determine the influence of biomarkers on clinical symptoms and disease outcomes in order to improve the clinical diagnosis, deliver appropriate information and care for patients and assist in the development of disease modifying therapies.

To determine the rates of change in clinical, cognitive, behavioural and imaging biomarkers participants with dementia with Lewy bodies will undergo clinical and cognitive assessments every 6 months; brain MRI scans every 18 months; amyloid brain PET imaging every 18 months; tau and dopaminergic brain PET imaging once at baseline; blood sample at baseline and optional cerebrospinal fluid collection once at baseline. The total obeservational period for each study participant will be 3 years.

To find out more about the study, please visit the  Australian & New Zealand Clinical Trials Registry page, or contact Lesley Vidaurre, the study coordinator, on +61 3 9389 2909

Lead clinician:

Dr Rosie Watson MBBS, FRACP, PhD

Consultant Physician in Geriatric Medicine

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