Huntington’s disease is an inherited single-gene abnormality that causes neurons in the brain to become dysfunctional and eventually die. The condition involves mental deficits (culminating in dementia), psychiatric symptoms like depression, and movement disorders. Huntington’s disease is one of the increasing numbers of fatal brain diseases known to be caused by DNA expansion (a ‘genetic stutter’) in the disease-causing gene.
Our research into Huntington’s disease has shown for the first time that depression can be modelled, and is reduced by enhanced mental and physical activity. We have also identified key molecules involved in the psychiatric elements of the disorder. This will have implications not only for this disease, but for depression in the wider community.
If you are seeking more information on living with Huntington's disease please follow the link below.